General Information

Salmeterol Impurities and Salmeterol

Daicel Pharma offers a comprehensive range of exclusive Salmeterol impurities such as Salmeterol EP Impurity G, Dimethyl-4-(benzyloxy)isophthalate,(4-(benzyloxy)-1,3-phenylene)dimethanol, Alpha-Hydroxy salmeterol, Benzylated amino methyl impurity of SAM-V, Salmeterol Related Impurity-2, Salmeterol Related Impurity-4, Salmeterol Related impurity-5, Salmeterol Related Impurity 7, and more. These impurities are critical in determining the active pharmaceutical ingredient Salmeterol’s quality, stability, and biological safety. Additionally, Daicel Pharma can synthesize Salmeterol impurities according to precise customer specifications while guaranteeing worldwide delivery.

Salmeterol [CAS: 89365-50-4] is a long-acting beta-agonist (LABA) medication for treating asthma with an inhaled corticosteroid. It prevents exercise-induced bronchospasm. In addition, Salmeterol is used to maintain airflow obstruction and prevent exacerbations in individuals with chronic obstructive pulmonary disease (COPD).

Salmeterol: Use and Commercial Availability  

Salmeterol is a maintenance therapy for COPD to help maintain airflow and prevent exacerbations. It is a long-acting beta-agonists (LABAs). Salmeterol relaxes and opens the airways, making breathing easier. It is a part of combination therapy, alongside an inhaled corticosteroid, for better management of asthma or COPD symptoms. Salmeterol is available under many brand names. Serevent effectively contains the active ingredient – Salmeterol.

Salmeterol Structure and Mechanism of Action

The chemical name of Salmeterol is 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol. Its chemical formula is C₂₅H₃₇NO4, and its molecular weight is approximately 415.6 g/mol.

Salmeterol is a selective beta2-adrenoceptor that causes bronchial smooth muscle relaxation, bronchodilation, and increased airflow.

Salmeterol Impurities and Synthesis

Impurities can arise during the synthesis¹ and storage of Salmeterol, including related substances, degradation products, or residual solvents. These impurities must be monitored and controlled to ensure the medication’s safety, efficacy, and quality.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Salmeterol impurity standards like Salmeterol EP Impurity G, Dimethyl-4-(benzyloxy)isophthalate,(4-(benzyloxy)-1,3-phenylene)dimethanol, Alpha-Hydroxy salmeterol, Benzylated amino methyl impurity of SAM-V, Salmeterol Related Impurity-2, Salmeterol Related Impurity-4, Salmeterol Related impurity-5, Salmeterol Related Impurity 7, and more. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional characterization data, including 13C-DEPT, upon request. Daicel Pharma offers to generate unknown impurities or degradation products of Salmeterol.