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Regulating impurities in Verapamil is crucial to maintain the drug's safety, effectiveness, and quality. They can impact the drug's potency, stability, and how it is absorbed in the body, potentially leading to adverse effects and reduced therapeutic outcomes.
Impurities in Verapamil can form during manufacturing, storage, and transportation. They can originate from starting materials, intermediates, or by-products of chemical reactions.
Impurities found in Verapamil can be classified into several categories, which include process-related contaminants, degradation products, residual solvents, and genotoxic impurities.
The recommendation is to store Verapamil impurities at room temperature, within 2-8 °C.
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