General Information

Verapamil Impurities and Verapamil

Daicel Pharma is a trusted provider of quality Verapamil impurity standards including, 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-oxopentanenitrile, 2-(3,4-dimethoxyphenyl)-5-((4-hydroxy-3-methoxyphenethyl)(methyl)amino)-2-isopropylpentanenitrile, 2-chloro-N-(3,4-dimethoxyphenethyl)-N-methylethan-1-amine, 3-bromo-N-(3,4-dimethoxyphenethyl)-N-methylpropan-1-amine and many more.

These impurities are crucial in meticulously evaluating the quality, stability, and safety of the active pharmaceutical ingredient, Verapamil. Furthermore, Daicel Pharma customizes Verapamil impurity standards, guaranteeing to meet individual client specifications. With global shipping capabilities, these impurities can be conveniently delivered to customers worldwide, offering unparalleled convenience.

Verapamil [CAS: 52-53-9] is a first-generation calcium channel blocker and treats hypertension, angina pectoris, and supraventricular tachyarrhythmias.

Verapamil: Use and Commercial Availability 

Verapamil treats various cardiovascular conditions. It is for vasospastic (Prinzmetal’s) angina, unstable, and chronic stable angina.  It effectively relaxes and widens blood vessels, reduces the workload on the heart, and helps regulate heart rhythm. Verapamil plays a vital role in controlling blood pressure, alleviating chest pain, and managing abnormal heart rhythms, ultimately improving the overall cardiovascular health of patients. Verapamil is available under the brand names Calan, Calan SR, Covera-HS, Verelan, Verelan PM and Isoptin.

Verapamil Structure and Mechanism of Action

The chemical name of Verapamil is α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile. Its molecular formula is C₂₇H₃₈N₂O₄, and its molecular weight is approximately 454.6 g/mol.

Verapamil selectively blocks the transmembrane influx of calcium ions into arterial smooth muscle cells and myocardial cells.

Verapamil Impurities and Synthesis

Verapamil impurities can arise during synthesis¹ due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Verapamil for patient use.

Daicel provides a comprehensive Certificate of Analysis (CoA) for Verapamil impurity standards, such as 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-oxopentanenitrile, 2-(3,4-dimethoxyphenyl)-5-((4-hydroxy-3-methoxyphenethyl)(methyl)amino)-2-isopropylpentanenitrile, 2-chloro-N-(3,4-dimethoxyphenethyl)-N-methylethan-1-amine, 3-bromo-N-(3,4-dimethoxyphenethyl)-N-methylpropan-1-amine and many more.

The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additionally, upon delivery, 13C-DEPT is also provided. Daicel possesses the technology and expertise to synthesize any unknown Verapamil impurity or degradation product. We also offer labeled compounds to quantify the efficacy of generic Verapamil. For bioanalytical research and BA/BE studies, Daicel supplies highly pure Nor-Verapamil D6 HCl, R-Nor Verapamil-D6. HCl, R-Verapamil-D6. HCl,  S-Verapamil.HCl-D6, S-Nor Verapamil.HCl-D6, Verapamil D6.HCl,  deuterium-labeled impurity standards of Verapamil.