Ticagrelor

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(1S,2S,3R,5S)-3-((5-amino-2-(propylthio)pyrimidin-...

  • CAT NUMBER DCTI-C-2662
  • CAS NUMBER NA
  • MOLECULAR FORMULA C14H24N4O4S
  • MOLECULAR WEIGHT 344.43

(1S,2S,3S,5R)-3-(2-hydroxyethoxy)-5-((5-nitro-2-(p...

  • CAT NUMBER DCTI-C-2663
  • CAS NUMBER NA
  • MOLECULAR FORMULA C14H22N4O6S
  • MOLECULAR WEIGHT 374.41

2-(2,3-difluorophenyl)cyclopropanamine hydrochloride

  • CAT Number DCTI-C-1585
  • CAS Number 1354951-34-0
  • Molecular Formula C9H9F2N (free base) C9H10ClF2N (HCl salt)
  • Molecular Weight 169.17 (free base) 205.63 (HCl salt)

2-(3,5-difluorophenyl)cyclopropanamine hydrochloride

  • CAT Number DCTI-C-1586
  • CAS Number 1511636-19-3 (free acid)
  • Molecular Formula C9H9F2N (free base) C9H10ClF2N (HCl salt)
  • Molecular Weight 169.17 (free base) 205.63 (HCl salt)

4,6-dichloro-2-(propylthio)pyrimidin-5-amine

  • CAT Number DCTI-C-1520
  • CAS Number 145783-15-9
  • Molecular Formula C7H9Cl2N3S (free base)
  • Molecular Weight 238.13

4,6-dichloro-5-nitro-2-(propylthio)pyrimidine

  • CAT Number DCTI-C-1519
  • CAS Number 145783-14-8
  • Molecular Formula C7H7Cl2N3O2S
  • Molecular Weight 268.11

Ethanol, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2...

  • CAT Number DCTI-C-1004
  • CAS Number 274693-55-9
  • Molecular Formula C10H19NO4
  • Molecular Weight 217.27

O-acetyl Ticagrelor

  • CAT Number DCTI-C-1587
  • CAS Number 1616703-93-5
  • Molecular Formula C25H30F2N6O5S
  • Molecular Weight 564.61

Ticagrelor acetonide

  • CAT Number DCTI-C-957
  • CAS Number 274693-26-4
  • Molecular Formula C26H32F2N6O4S
  • Molecular Weight 562.63
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General Information

Ticagrelor Impurities and Ticagrelor

Daicel Pharma is a reliable source for synthesizing high-quality Ticagrelor impurities like (1S,2S,3R,5S)-3-((5-amino-2-(propylthio)pyrimidin-4-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol,2-(2,3-difluorophenyl)cyclopropanamine hydrochloride, 2-(3,5-difluorophenyl)cyclopropanamine hydrochloride, O-acetyl Ticagrelor, Ticagrelor acetonide, Ticagrelor amine impurity AR-C133913XX and many more. These impurities are essential in accurately analyzing the Ticagrelor quality, stability, and biological safety. Additionally, Daicel Pharma offers a customized synthesis of Ticagrelor impurities for global delivery to meet the specific needs of our customers.

Ticagrelor [CAS: 274693-27-5] is a P2Y12 receptor antagonist. It lowers the likelihood of myocardial infarction and ischemic stroke.

Ticagrelor: Use and Commercial Availability

Ticagrelor lowers the risk of myocardial infarction and ischemic stroke by inhibiting thrombus formation. This medication reduces the risk of cardiovascular death, myocardial infarction, and stroke in individuals with acute coronary syndrome or a history of myocardial infarction.

Ticagrelor is available under Brilinta, which contains the active ingredient, Ticagrelor.

Ticagrelor Structure and Mechanism of ActionTicagrelor Structure and Mechanism of Action

The chemical name of Ticagrelor is (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol. Its chemical formula is C23H28F2N6O4S, and its molecular weight is approximately 522.6 g/mol.

Ticagrelor prevents signal transduction and platelet activation by reversibly interacting with the platelet P2Y12 ADP receptor.

Ticagrelor Impurities and Synthesis

During Ticagrelor manufacturing1, impurity formation is possible, compromising its effectiveness. They can arise from various sources, including the raw materials, intermediates, and chemicals utilized to synthesize Ticagrelor. To ensure the drug’s optimal efficacy and safety, closely managing and monitoring these impurities is paramount.

Daicel offers a wholesome and integrated Certificate of Analysis (CoA) for Ticagrelor impurity standards, encompassing(1S,2S,3R,5S)-3-((5-amino-2-(propylthio)pyrimidin-4-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, 2-(2,3-difluorophenyl)cyclopropanamine hydrochloride, 2-(3,5-difluorophenyl)cyclopropanamine hydrochloride, O-acetyl Ticagrelor, Ticagrelor acetonide, Ticagrelor amine impurity AR-C133913XX and many more. The Certificate of Analysis (CoA) offers detailed characterization data, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity2, ensuring comprehensive information about the product. Furthermore, Daicel Pharma possesses advanced technological capabilities and expertise to synthesize any unknown impurities or degradation products of Ticagrelor.

References
FAQ's

Frequently Asked Questions

Analytical methods, such as high-performance liquid chromatography (HPLC), are commonly used to detect and quantify impurities in Ticagrelor batches.

The specifications for Ticagrelor impurities are determined through meticulous research, analysis, and adherence to regulatory guidelines. Essential factors, including toxicological studies, clinical data, and regulatory considerations, are thoroughly evaluated to establish acceptable limits for impurity levels.

A chiral column separation technique helps identify the chiral isomer and employs a self-contrast approach without needing a correction factor to quantify impurities. Experimental results demonstrate that the chosen chromatographic conditions effectively separate the main component and its chiral isomer, allowing for better control over the mass of the Ticagrelor crude drug.

Ticagrelor impurities are stored at a controlled room temperature, between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

 

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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