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Sorafenib

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Sorafenib Impurity-D
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Sorafenib Impurity-D

  • CAT Number DCTI-C-1305
  • CAS Number 2206827-14-5
  • Molecular Formula C17H19N3O4
  • Molecular Weight 329.36
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Sorafenib Impurity-E
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Sorafenib Impurity-E

  • CAT Number DCTI-C-1307
  • CAS Number 284670-98-0
  • Molecular Formula C27H24N6O5
  • Molecular Weight 512.53
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Sorafenib Impurity-F
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Sorafenib Impurity-F

  • CAT Number DCTI-C-1308
  • CAS Number 1285533-84-7
  • Molecular Formula C21H17F3N4O3
  • Molecular Weight 430.39
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Sorafenib N-Oxide
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Sorafenib N-Oxide

  • CAT Number DCTI-C-1079
  • CAS Number 583840-03-3
  • Molecular Formula C21H16ClF3N4O4
  • Molecular Weight 480.82
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References
FAQ's

References

  1. Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; et al, omega -Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors, Bayer Corporation, United States, WO00042012A1, July 20, 2000
  1. Zhao, Ming; Rudek, Michelle A.; He, Ping; Hafner, Frank-Thorsten; Radtke, Martin; Wright, John J.; Smith, B. Douglas; Messersmith, Wells A.; Hidalgo, Manuel; Baker, Sharyn D., A rapid and sensitive method for determination of sorafenib in human plasma using a liquid chromatography/tandem mass spectrometry assay, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Volume: 846, Issue: 1-2, Pages: 1-7, 2007

Frequently Asked Questions

Manufacturers can adopt several strategies to maintain control over impurity levels in Sorafenib. They include using high-quality starting materials, optimizing synthesis and purification processes, implementing comprehensive quality control tests, and continuously monitoring impurity levels at different stages of the manufacturing process.

Inorganic impurities in Sorafenib can be due to the raw materials used during manufacturing, which may include substances such as heavy metals or other contaminants—underscoring the importance of vigilant monitoring and stringent control measures to uphold Sorafenib's quality and safety standards as a pharmaceutical product.

Depending on the type and level of impurities, they can impact the drug's pharmacological activity and stability and pose potential risks to patient health.

Sorafenib Impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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