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Palbociclib

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Palbociclib N-Boc Impurity

  • CAT NUMBER DCTI-C-2371
  • CAS NUMBER 1651214-74-2
  • MOLECULAR FORMULA C29H37N7O4
  • MOLECULAR WEIGHT 547.66
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Palbociclib N-Hydroxy Piperazine

  • CAT NUMBER DCTI-C-2644
  • CAS NUMBER 2231085-26-8
  • MOLECULAR FORMULA C24H29N7O3
  • MOLECULAR WEIGHT 463.54
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Palbociclib Nitroso Impurity

  • CAT NUMBER DCTI-C-2368
  • CAS NUMBER NA
  • MOLECULAR FORMULA C24H28N8O3
  • MOLECULAR WEIGHT 476.54
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Palbociclib Pyridine N-Oxide HCl Salt

  • CAT NUMBER DCTI-C-2373
  • CAS NUMBER 2098673-40-4 (Free Base); 2098673-44-8 (HCl Salt)
  • MOLECULAR FORMULA C24H29N7O3 (Free Base); C24H30ClN7O3 (HCl Salt)
  • MOLECULAR WEIGHT 463.54 (Free base); 500.0 (HCl Salt)
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Palbociclib-DCTI-C-724-Daicel
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Palbociclib Sulphonation Impurity

  • CAT Number DCTI-C-724
  • CAS Number 2204863-10-3
  • Molecular Formula C24H29N7O5S
  • Molecular Weight 527.6
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Palbociclib-2,6-bis-aminopyridine impurity

  • CAT NUMBER DCTI-C-2370
  • CAS NUMBER 2458234-37-0
  • MOLECULAR FORMULA C31H39N11O
  • MOLECULAR WEIGHT 581.73
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Palbociclib-DCTI-C-265-Daicel
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Palbociclib-d8

  • CAT Number DCTI-A-265
  • CAS Number 1628752-83-9
  • Molecular Formula C24H21D8N7O2
  • Molecular Weight 455.59
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Palbociclib-DCTI-C-698-Daicel
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Palbociclib-N-Alkylation Impurity+C10:C12

  • CAT Number DCTI-C-698
  • CAS Number NA
  • Molecular Formula C22H28ClN7O2 (HCl Salt) C22H27N7O2 (Free base)
  • Molecular Weight 457.96 (HCl Salt) 421.51 (Free base)
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Palbociclib-DCTI-C-699-Daicel
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Palbociclib-N-Formyl Impurity

  • CAT Number DCTI-C-699
  • CAS Number 2174002-16-3
  • Molecular Formula C25H29N7O3
  • Molecular Weight 475.55
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References
FAQ's

References

  1. Barvian, Mark Robert; Booth, Richard John; Quin, John, III; Repine, Joseph Thomas; Sheehan, Derek James; Toogood, Peter Laurence; Vanderwel, Scott Norman; Zhou, Hairong, “2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones”, Warner-Lambert Company Llc, United States, US6936612B2, August 30, 2005
  2. Ma, Xingling; Liu, Lei; Cao, Na; Zou, Qiaogen; Xiong, Kaihe; Ouyang, Pingkai, “Isolation and structural elucidation of Palbociclib's eight process-related impurities: two identified as new compounds”, Journal of AOAC International, Volume: 99, Issue: 3, Pages: 638-648, 2016

Frequently Asked Questions

The potential sources of impurities in Palbociclib include starting materials, reagents, solvents, degradation products, and processing aids used during manufacturing.

Analytical methods such as HPLC, and LC-MS help identify and quantify Palbociclib impurities.

Impurities in Palbociclib are monitored during stability studies using validated analytical methods to ensure that the drug product remains within the specified limits over the shelf life of the product.

The recommended storage temperature for Palbociclib Impurities is 2-8°C in general. However, it depends upon the stability of the compound.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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