General Information

Ondansetron Impurities and Ondansetron 

Daicel Pharma offers Ondansetron impurities that involve Ondansetron impurity-C, Ondansetron Impurity-G, Ondansetron Impurity-H, Ondansetron Impurity-I, Ondansetron Related Compound A, Ondansetron Related compound – D. These impurities have a role in determining the quality, stability, and safety of Ondansetron, a pharmaceutically active component. Daicel Pharma is capable of synthesizing Ondansetron impurities and distributing them worldwide.

Ondansetron [CAS: 99614-02-5] works as a serotonin type-3 antagonist for treating nausea and vomiting.

Ondansetron: Use and Commercial Availability  

Ondansetron reduces nausea and vomiting caused by emetogenic cancer treatment, postoperative care, and radiation. It helps to alleviate postoperative nausea and vomiting. Ondansetron is a frequently used medication for children and teens following head trauma and concussion. Ondansetron comes in different dosage forms, including oral pills, disintegrating tablets, and injectables. It is widely available commercially under several brand names, Zofran and Zuplenz.

Ondansetron Structure and Mechanism of Action

The chemical name of Ondansetron is 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one. Its chemical formula is C₁₈H₁₉N₃O, and its molecular weight is approximately 293.4 g/mol.

Its mechanism of action is not known.

Ondansetron Impurities and Synthesis

During the synthesis of Ondansetron impurities, a medication commonly used to prevent nausea and vomiting, impurities can form. These impurities may arise from incomplete reactions, undesired side reactions, or contaminants in the starting materials or reagents. The synthesis¹ of Ondansetron involves multiple steps, including reacting various intermediates to form the final product.

Daicel provides a Certificate of Analysis (CoA) of Ondansetron impurity standards such as Ondansetron impurity-C, Ondansetron Impurity-G, Ondansetron Impurity-H, Ondansetron Impurity-I, Ondansetron Related Compound A, and Ondansetron Related compound – D. Daicel delivers a Certificate of Analysis (CoA) from a cGMP-certified analytical facility for Ondansetron impurities. Our CoA contains extensive characterization information, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional characterization information, including 13C-DEPT, on request. Our specialists provide the extremely pure Ondansetron D3, Ondansetron 13CD3, deuterated-labeled standards of Ondansetron needed for bioanalytical research, and Bioavailability/Bioequivalence (BA/BE) studies.