Metoprolol

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1,3-Bis(isopropylamino)propan-2-ol

  • CAT NUMBER DCTI-C-2082
  • CAS NUMBER 73313-36-7
  • MOLECULAR FORMULA C9H22N2O (Free base); C9H24Cl2N2O (HCl Salt)
  • MOLECULAR WEIGHT 174.29 (Free base); 247.20 (HCl Salt)

Metoprolol Bis propanol

  • CAT NUMBER DCTI-C-2083
  • CAS NUMBER 230975-30-1
  • MOLECULAR FORMULA C21H28O5
  • MOLECULAR WEIGHT 360.45

Metoprolol EP Impurity B

  • CAT NUMBER DCTI-C-2079
  • CAS NUMBER 56718-71-9
  • MOLECULAR FORMULA C9H12O2
  • MOLECULAR WEIGHT 152.19

Metoprolol EP Impurity D

  • CAT NUMBER DCTI-C-2075
  • CAS NUMBER 62572-90-1
  • MOLECULAR FORMULA C12H18O4
  • MOLECULAR WEIGHT 226.27

Metoprolol EP Impurity F

  • CAT NUMBER DCTI-C-2081
  • CAS NUMBER 7695-63-8
  • MOLECULAR FORMULA C12H19NO2
  • MOLECULAR WEIGHT 209.29

Metoprolol EP Impurity G

  • CAT NUMBER DCTI-C-2078
  • CAS NUMBER 501-94-0
  • MOLECULAR FORMULA C8H10O2
  • MOLECULAR WEIGHT 138.17

Metoprolol EP Impurity H

  • CAT NUMBER DCTI-C-2077
  • CAS NUMBER 62572-94-5
  • MOLECULAR FORMULA C14H23NO3
  • MOLECULAR WEIGHT 253.34

Metoprolol EP Impurity J

  • CAT NUMBER DCTI-C-2076
  • CAS NUMBER 163685-37-8
  • MOLECULAR FORMULA C18H31NO5
  • MOLECULAR WEIGHT 341.45

Metoprolol EP Impurity N

  • CAT NUMBER DCTI-C-2074
  • CAS NUMBER NA
  • MOLECULAR FORMULA C6H15N1O2 (Free base); C6H16ClNO2 (HCl Salt)
  • MOLECULAR WEIGHT 133.19 (Free base); 169.65 (HCl Salt)
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General Information

Metoprolol Impurities and Metoprolol

Daicel Pharma is a trusted provider of quality Metoprolol impurity standards, including 1,3-Bis(isopropylamino)propan-2-ol, Metoprolol Bis propanol, Metoprolol EP Impurity B, Metoprolol EP Impurity F, Metoprolol EP Impurity G, Metoprolol EP Impurity J, Ortho-metoprolol and many more. These impurities are critical in determining the active pharmaceutical ingredient Metoprolol’s quality, stability, and biological safety. Additionally, Daicel Pharma can synthesize Metoprolol impurities according to precise customer specifications while guaranteeing worldwide delivery.

Metoprolol [CAS: 51384-51-1] is a selective beta-blocker widely used to treat hypertension and angina pectoris.

Metoprolol: Use and Commercial Availability   

Metoprolol treats angina pectoris, myocardial infarction, heart failure, atrial fibrillation, atrial flutter, and hypertension. It is a selective beta-1 blocker that treats many cardiovascular diseases.

Metoprolol is available under the brand names Kaspargo Sprinkle, Lopressor, and Toprol-XL, which contains the active ingredient Metoprolol.

Metoprolol Structure and Mechanism of Action Metoprolol Structure and Mechanism of Action

The chemical name of Metoprolol is 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol. Its chemical formula is C15H25NO3, and its molecular weight is approximately 267.36 g/mol.

Metoprolol blocks beta2-adrenoreceptors located in the bronchial and vascular muscles.

Metoprolol Impurities and Synthesis

Metoprolol impurities can arise during synthesis1 due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Metoprolol for patient use.

Daicel Pharma provides a comprehensive Certificate of Analysis (CoA) for Metoprolol impurity standards, such as 1,3-Bis(isopropylamino)propan-2-ol, Metoprolol Bis propanol, Metoprolol EP Impurity B, Metoprolol EP Impurity F, Metoprolol EP Impurity G, Metoprolol EP Impurity J, Ortho-metoprolol and many more.  The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, a complete 13C-DEPT is also provided. Daicel possesses the technology and expertise to synthesize any unknown Metoprolol impurity or degradation product. We offer Metoprolol Labelled Standard, deuterium-labeled impurity standards of Metoprolol, which are essential in BA/BE studies.

References
FAQ's

Frequently Asked Questions

Analytical Methods like reverse-phase ultra-performance liquid chromatographic method have been developed to estimate Metoprolol impurities quantitatively.

Yes, impurities in Metoprolol can impact patient safety. Depending on their nature and concentration, contaminants can cause adverse effects or reduce the efficacy of the medication.

Methanol is employed to attain the ideal solubility and differentiation of impurities in Metoprolol.

Metoprolol impurities should generally be stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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