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Methotrexate

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Methotrexate-DCTI-C-1408-Daicel
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Methotrexate Impurity H

  • CAT Number DCTI-C-1408
  • CAS Number 67022-39-3
  • Molecular Formula C21H24N8O5
  • Molecular Weight 468.47
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Methotrexate-DCTI-C-1413-daicelpharma
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Methotrexate Impurity I

  • CAT Number DCTI-C-1413
  • CAS Number 66147-29-3 (free base)
  • Molecular Formula C21H24N8O5 (Free base) 22H26N8O7(Salt)
  • Molecular Weight 468.47 (Free base) 514.50 (Salt)
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Methotrexate γ-Ethyl Ester

  • CAT NUMBER DCTI-C-3084
  • CAS NUMBER 65148-64-3 (Free base)
  • MOLECULAR FORMULA C24H27F3N8O7 (with Salt); C22H26N8O5 (Free Acid)
  • MOLECULAR WEIGHT 596.52 (With Salt); 482.50 (Free Acid)
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Methotrexate-DCTI-A-244-daicelpharma
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Methotrexate-d3

  • CAT Number DCTI-A-244
  • CAS Number 432545-63-6
  • Molecular Formula C20H19D3N8O5
  • Molecular Weight 457.47
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References
FAQ's

References

  1. Catalucci, Enrico, Process for the production of methotrexate, Lonza A.-G., Switzerland, US4224446A, September 23, 1980
  2. Chatterji, Dulal C.; Gallelli, Joseph F., High-pressure liquid chromatographic analysis of methotrexate in presence of its degradation products, Journal of Pharmaceutical Sciences Volume: 66, Issue: 9, Pages: 1219-22, 1977

Frequently Asked Questions

Yes, specific tests are conducted to identify impurities in Methotrexate. Analytical methods such as high-performance liquid chromatography (HPLC), liquid chromatography (LC), or mass spectrometry (MS) help separate and detect impurities in the drug.

Purification processes can help reduce impurities in Methotrexate. Techniques such as recrystallization, filtration, or chromatography are used during manufacturing to remove impurities and improve the drug's purity.

DMSO is the solvent used when analyzing many impurities in Methotrexate.

Methotrexate impurities should be stored, at a controlled room temperature, usually between 2-8 °C.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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