General Information

Liraglutide Impurities and Liraglutide 

Daicel Pharma synthesizes high-quality Liraglutide impurities, Des-Gly (29)-Liraglutide, Des-Gly (4)-Liraglutide, Des-Ser (8)-Liraglutide, Glu (17)-Liraglutide, Kyn (25)-Liraglutide, and Trp(O)-Liraglutide, which helps in quality, stability, and biological safety analysis of the API of Liraglutide. We offer custom synthesis of Liraglutide impurities and can supply globally.

Liraglutide [CAS: 204656-20-2] is a medication categorized as a Glucagon-Like Peptide-1 (GLP-1) receptor agonist. It is commonly used to treat type 2 diabetes and prevent cardiovascular complications that may arise due to diabetes.

Liraglutide: Use and Commercial Availability

Liraglutide, available under the brand name Saxenda, is used to treat chronic weight management. It aids long-term weight management in adults with obesity (BMI≥30 kg/m2) or overweight (BMI≥27 kg/m2) and at least one weight-related comorbidity such as hypertension, dysglycaemia, etc. It is indicated as an adjunct to a reduced-calorie diet.

Victoza, another brand under which Liraglutide is available, improves glycemic control in patients aged 10 or older with type 2 diabetes mellitus. It also minimizes the risk of major adverse cardiovascular events in adult patients with type 2 diabetes and established cardiovascular disease. It is available as a solution in subcutaneous injection, a pre-filled multi-dose pen that delivers doses of Liraglutide to the patients¹.

Liraglutide Structure and Mechanism of Action

The chemical formula of Liraglutide is C₁₇₂H₂₆₅N₄₃O₅₁ and its molecular weight is approximately 3751.2 g/mol.

Liraglutide is a synthetic, acylated human glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 receptor is present in various areas of the brain involved in appetite regulation.  It also inhibits the glucose-dependent release of glucagon and slows down gastric emptying, ultimately helping to regulate blood sugar levels more effectively.

Liraglutide Impurities and Synthesis

Liraglutide synthesis uses recombination technology in yeast and is chemically modified by the addition of the Glu-spaced hexadecanoic (palmitic) acid² Liraglutide impurities include related substances, degradation products, residual solvents, inorganic impurities, and microbial impurities³. The manufacturers of Liraglutide perform rigorous analytical testing to detect and quantify these impurities to ensure the quality and safety of the drug.

At Daicel, we provide a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Liraglutide impurity standards, Des-Gly (29)-Liraglutide, Des-Gly (4)-Liraglutide, Des-Ser (8)-Liraglutide, Glu (17)-Liraglutide, Kyn (25)-Liraglutide, and Trp(O)-Liraglutide, with complete characterization data including 1H NMR, 13C NMR, IR, MS³, and HPLC purity. We also provide 13C-DEPT and CHN on request. Further, we provide a complete characterization report upon delivery. Daicel offers highly pure isotope-labeled standards of Liraglutide in bioanalytical research and BA/BE studies. Bioanalytical data is vital in the development of chemical and biological drugs with isotope data in CoA.