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Dexmedetomidine

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Dexmedetomidine-DCTI-C-524-Daicel
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Dexmedetomidine Impurity-6 Other Isomer

  • CAT Number DCTI-C-524
  • CAS Number 1311376-20-1
  • Molecular Formula C20H20N2
  • Molecular Weight 288.39
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Dexmedetomidine N-Methyl ester Impurity
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Dexmedetomidine N-Methyl ester Impurity

  • CAT Number DCTI-C-2003
  • CAS Number NA
  • Molecular Formula C15H18N2O2
  • Molecular Weight 258.32
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Dexmedetomidine-DCTI-C-410-Daicel
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Dexmedetomidine Potential impurity

  • CAT Number DCTI-C-410
  • CAS Number 1311376-20-1
  • Molecular Formula C20H20N2
  • Molecular Weight 288.39
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Dexmedetomidine Potential impurity 5

  • CAT Number DCTI-C-409
  • CAS Number 1021949-47-2
  • Molecular Formula C13H14N2
  • Molecular Weight 198.27
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Dexmedetomidine-DCTI-C-454-Daicel
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Dexmedetomidine Potential Impurity-1

  • CAT Number DCTI-C-454
  • CAS Number 2250243-44-6
  • Molecular Formula C20H22N2O
  • Molecular Weight 306.41
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Dexmedetomidine-DCTI-C-457-Daicel
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Dexmedetomidine Potential Impurity-3 Hydrochloride

  • CAT Number DCTI-C-457
  • CAS Number 2250242-52-3 (Free base)
  • Molecular Formula C20H23ClN2 (HCl Salt) C20H22N2 (Free Base)
  • Molecular Weight 326.87 (HCl Salt) 290.41 (Free Base)
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Dexmedetomidine-DCTI-C-1157-Daicel
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Dexmedetomidine Potential Impurity-3 hydrochloride other isomer

  • CAT Number DCTI-C-1157
  • CAS Number 2197018-01-0 (free base)
  • Molecular Formula C20H22N2
  • Molecular Weight 290.41
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Dexmedetomidine-DCTI-C-408-Daicel
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Dexmedetomidine Potential impurity-4

  • CAT Number DCTI-C-408
  • CAS Number 86347-12-8
  • Molecular Formula C13H16N2O
  • Molecular Weight 216.28
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Dexmedetomidine-DCTI-C-456-Daicel
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Dexmedetomidine Potential Impurity-6 Hydrochloride

  • CAT Number DCTI-C-456
  • CAS Number 2250243-56-0 (Free base)
  • Molecular Formula C20H21ClN2 (HCl Salt) C20H20N2 (Free Base)
  • Molecular Weight 324.85 (HCl Salt) 288.39 (Free Base)
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References
FAQ's

References

  1. Karjalainen, Arto Johannes; Virtanen, Raimo Einari; Savolainen, Eino Juhani, Optical Isomers Of An Imidazole Derivative, Farmos-Yhtyma Oy, Finland, GB2206880B, April 24, 1991
  2. Hui, Y.-H.; Marsh, K. C.; Menacherry, S., Analytical method development for the simultaneous quantitation of dexmedetomidine and three potential metabolites in plasma, Journal of Chromatography A, Volume: 762, Issue: 1 + 2, Pages: 281-291, 1997
  3. Ji, Qin C.; Zhou, Julie Y.; Gonzales, R. John; Gage, Eric M.; El-Shourbagy, Tawakol A., Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detection, Rapid Communications in Mass Spectrometry, Volume: 18, Issue: 15, Pages: 1753-1760, 2004

Frequently Asked Questions

Dexmedetomidine impurities help ensure the drug's quality, safety, and efficacy. Controlling impurities help maintain the desired pharmacological properties, reduces the risk of adverse effects, and ensures compliance with regulatory standards.

Impurities in Dexmedetomidine are analyzed using various analytical techniques such as chromatography (HPLC, LC), spectroscopy (UV, IR), mass spectrometry (MS), and other advanced methods. These techniques help in the identification, quantification, and characterization of impurities.

Methanol and Water are the solvents used in analyzing many impurities in Dexmedetomidine.

Dexmedetomidine impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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