Voriconazole

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Voriconazole Diastereomer (2S,3S/2R,3R) impurity

  • CAT Number DCTI-C-2196
  • CAS Number 239807-03-5
  • Molecular Formula C16H14F3N5O
  • Molecular Weight 349.32

Voriconazole EP Impurity A

  • CAT Number DCTI-C-2197
  • CAS Number 86404-63-9
  • Molecular Formula C10H7F2N3O
  • Molecular Weight 223.18

Voriconazole EP Impurity C

  • CAT Number DCTI-C-2198
  • CAS Number 137234-88-9
  • Molecular Formula C6H7FN2
  • Molecular Weight 126.13

Voriconazole Impurity-15

  • CAT Number DCTI-C-2194
  • CAS Number 321589-00-8
  • Molecular Formula C22H19F4N7O
  • Molecular Weight 473.44

Voriconazole impurity-D

  • CAT Number DCTI-C-2195
  • CAS Number 137234-63-0
  • Molecular Formula C16H14F3N5O
  • Molecular Weight 349.32

General Information

Voriconazole Impurities and Voriconazole

Daicel Pharma is a trusted provider of quality Voriconazole impurity standards, including Voriconazole Diastereomer (2S,3S/2R,3R) impurity, Voriconazole EP Impurity A, Voriconazole EP Impurity C, Voriconazole Impurity-15 and Voriconazole EP Impurity D. These impurities are crucial in meticulously evaluating the quality, stability, and safety of the active pharmaceutical ingredient, Voriconazole. Furthermore, Daicel Pharma customizes Voriconazole impurities, guaranteeing to meet client specifications. With global shipping capabilities, these impurities can be conveniently delivered to customers worldwide, offering unparalleled convenience.

Voriconazole [CAS: 137234-62-9] is an antifungal medication commonly used prophylactically and treats fungal infections in lung and bone transplant patients.

Voriconazole: Use and Commercial Availability 

Voriconazole is an antifungal agent belonging to the triazole class, sharing structural similarities with fluconazole but exhibiting an expanded range of activity. It is frequently used as a preventive measure and for treating fungal infections in patients who have undergone lung and bone transplants. Additionally, it treats invasive fusariosis and scedosporiosis.

Voriconazole is available under the brand name Vfend.

Voriconazole Structure and Mechanism of ActionVoriconazole Structure and Mechanism of Action

The chemical name of Voriconazole is (αR, βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol. Its chemical formula is C16H14F3N5O, and its molecular weight is approximately 349.31 g/mol.

Voriconazole inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation. Its antifungal activity is due to the accumulation of 14-alpha methyl sterols.

Voriconazole Impurities and Synthesis

Voriconazole impurities can arise during synthesis1 due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Voriconazole for patient use.

Daicel provides a comprehensive Certificate of Analysis (CoA) for Voriconazole impurity standards, such as Voriconazole Diastereomer (2S,3S/2R,3R) impurity, Voriconazole EP Impurity A, Voriconazole EP Impurity C, Voriconazole Impurity-15 and Voriconazole EP Impurity D. The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, we give a complete 13C-DEPT. Daicel possesses the technology and expertise to synthesize any unknown Voriconazole impurity or degradation product.

References
FAQ's

Frequently Asked Questions

The impurities can affect the potency of Voriconazole, potentially reducing its effectiveness in treating some conditions.

Impurities can accelerate the degradation of Voriconazole, leading to shorter shelf life.

DMSO is the solvent used in analyzing many impurities in Voriconazole.

Determination of Voriconazole and its impurities are detected using High-Performance Liquid Chromatography with Ultra-Violet Detection.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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