General Information

Velpatasvir Impurities and Velpatasvir

Daicel Pharma is a trusted provider of quality Velpatasvir impurity standards. These impurities are crucial in meticulously evaluating the quality, stability, and safety of the active pharmaceutical ingredient, Velpatasvir. Furthermore, Daicel Pharma customizes Velpatasvir impurities, guaranteeing they meet client specifications. With global shipping capabilities, these impurities can be conveniently delivered to customers worldwide, offering unparalleled convenience.

Velpatasvir [CAS: 1377049-84-7] combines with other antiviral medications to treat chronic Hepatitis C Virus (HCV) infection in patients with HCV genotypes 1-6. It also treats HIV-co-infected patients.

Velpatasvir: Use and Commercial Availability 

Velpatasvir is a highly effective medication used to treat chronic hepatitis C virus (HCV) infections. It is primarily prescribed with other antiviral drugs, providing comprehensive therapy for HCV genotypes 1-6. Additionally, Velpatasvir is beneficial in managing HCV and HIV co-infection, making it a valuable treatment option for patients with dual infections. Velpatasvir helps improve liver health and overall well-being in individuals with chronic hepatitis C. Velpatasvir alone is currently unavailable under brand names.

Velpatasvir Structure and Mechanism of Action

The chemical name of Velpatasvir is Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate. Its chemical formula is C₄₉H₅₄N₈O_8, and its molecular weight is approximately 883.0 g/mol.

Velpatasvir inhibits the HCV NS5A protein responsible for virus replication.

Velpatasvir Impurities and Synthesis 

Velpatasvir impurities can arise during synthesis¹ due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Velpatasvir for patient use.

Daicel provides a comprehensive Certificate of Analysis (CoA) for Velpatasvir impurity standards. The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additionally, upon delivery, we give 13C-DEPT. Daicel possesses the technology and expertise to synthesize any unknown Velpatasvir impurity or degradation product. We also offer labeled compounds to quantify the efficacy of generic Velpatasvir. For bioanalytical research and BA/BE studies, Daicel supplies highly pure Velpatasvir-13CD3 and Velpatasvir-D3, deuterium-labeled compounds of Velpatasvir.