General Information

Tranylcypromine Impurities and Tranylcypromine

Daicel Pharma is a reliable source for synthesizing high-quality Tranylcypromine impurity standards like Cis-Hydrazide, S (-) Enantiomer of Tranylcypromine, Trans-Hydrazide, R (+) Enantiomer of Tranylcypromine and many more. These impurities aid in evaluating the active pharmaceutical ingredient, Tranylcypromine quality, stability, and safety. Daicel Pharma also provides a custom synthesis of Tranylcypromine impurities that can be shipped anywhere worldwide to meet clients’ requirements.

Tranylcypromine [CAS: 155-09-9] is an antidepressant medication that belongs to the class of nonhydrazine monoamine oxidase inhibitors (MAO inhibitors) that treats severe depression.

Tranylcypromine: Use and Commercial Availability 

Tranylcypromine is used to treat depressive disorder without melancholia. The medication is to treat resistant depression, resistant social anxiety disorder, resistant panic disorder, and atypical depression. Hyperphagia, hypersomnia, rejection sensitivity, and leaden paralysis are atypical depression.

Tranylcypromine is available under brand names such as Parnate, containing the active ingredient, Tranylcypromine.

Tranylcypromine Structure and Mechanism of Action

The chemical name of Tranylcypromine is rel-(1R,2S)-2-Phenylcyclopropanamine. Its chemical formula is C₉H₁₁N, and its molecular weight is approximately 133.19 g/mol.

Tranylcypromine irreversibly inhibits monoamine oxidase (MAO)n and eases depression symptoms.

Tranylcypromine Impurities and Synthesis

Tranylcypromine’s preparation¹ process can develop impurities, which could diminish its effectiveness. They may come from various raw materials, intermediates, and chemicals used in synthesizing Tranylcypromine, among other sources. It is necessary to manage and monitor these impurities closely to ensure the drug’s efficacy and safety.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Tranylcypromine impurity standards such as Cis-Hydrazide, S (-) Enantiomer of Tranylcypromine, Trans-Hydrazide, R (+) Enantiomer of Tranylcypromine and many more.  The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We also provide 13C-DEPT on request. Upon delivery, we give a complete characterization report. Daicel has the technology and expertise to prepare any unknown Tranylcypromine impurity or degradation product. We also provide labeled compounds to quantify the efficacy of generic Tranylcypromine. Daicel offers highly pure R-Tranylcypromine-D5 Hydrochloride and S-Tranylcypromine-D5 Hydrochloride, deuterium-labeled impurities of Tranylcypromine for bioanalytical research and BA/BE studies.