Sumatriptan

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Indole Acetic Acid Analogue of Sumatriptan. Formate salt

  • CAT NUMBER DCTI-C-2740
  • CAS NUMBER 103628-44-0 (Free Base)
  • MOLECULAR FORMULA C12H14N2O4S (Free Base); C13H16N2O6S (Formate Salt)
  • MOLECULAR WEIGHT 282.31 (Free Base); 328.34 (Formate Salt)

Sumatriptan D6 Format Salt

  • CAT NUMBER DCTI-A-272
  • CAS NUMBER NA
  • MOLECULAR FORMULA C14H15D6N3O2S (Free Base); C15H17D6N3O4S (format Salt)
  • MOLECULAR WEIGHT 301.44 (Free Base); 347.46 (format Salt)

Sumatriptan EP Impurity E

  • CAT Number DCTI-C-1766
  • CAS NUMBER NA
  • MOLECULAR FORMULA C12H17N3O2S
  • MOLECULAR WEIGHT 267.35

Sumatriptan Impurity 2

  • CAT Number DCTI-C-1106
  • CAS Number 2250254-19-2
  • Molecular Formula C14H21N3O4S
  • Molecular Weight 327.4

Sumatriptan Impurity-A

  • CAT Number DCTI-C-142
  • CAS Number 545338-89-4
  • Molecular Formula C27H37N5O2S
  • Molecular Weight 495.69

Sumatriptan impurity-F

  • CAT Number DCTI-C-1169
  • CAS Number 2074615-63-5
  • Molecular Formula C13H17N3O2S
  • Molecular Weight 279.36

Sumatriptan Metabolite

  • CAT NUMBER DCTI-C-2846
  • CAS NUMBER 88919-50-0
  • MOLECULAR FORMULA C13H19N3O2S
  • MOLECULAR WEIGHT 281.37

Sumatriptan Metabolite Ester Glucuronide of GR49336

  • CAT NUMBER DCTI-C-2862
  • CAS NUMBER 151751-50-7
  • MOLECULAR FORMULA C18H22N2O10S
  • MOLECULAR WEIGHT 458.44

Sumatriptan N-oxide

  • CAT Number DCTI-C-246
  • CAS Number 212069-94-8
  • Molecular Formula C14H21N3O3S
  • Molecular Weight 311.4
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General Information

Sumatriptan Impurities and Sumatriptan 

Daicel Pharma synthesizes high-quality Sumatriptan impurities like Sumatriptan EP Impurity E, Sumatriptan Impurity 2, Sumatriptan Impurity BP Imp-1/Sumatriptan pyrroloindolium analog, Sumatriptan Impurity-A, Sumatriptan impurity-F, Sumatriptan N-oxide, and Sumatriptan Succinate Impurity, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Sumatriptan. Moreover, Daicel Pharma offers custom synthesis of Sumatriptan impurities and delivers them globally.

Sumatriptan [CAS: 103628-46-2] is an FDA-approved medicine treating migraine attacks. It treats cluster headache episodes through subcutaneous administration. It is a sulfonamide triptan that causes vasoconstriction of cranial and basilar arteries.

Sumatriptan

Sumatriptan is effective and well-tolerated medicine for migraines, whether administered intranasally, subcutaneously, or orally. Its use helps to relieve photophobia, nausea, headache, and functional disability. Sumatriptan is available under brand names such as Alsuma, Imitrex, Onzetra Xsail, Sumavel Dosepro, Tosymra, Zecuity, and Zembrace Symtouch.

Sumatriptan Structure and Mechanism of Action Sumatriptan Structure and Mechanism of Action

The chemical name of Sumatriptan is 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide. Its chemical formula is C14H21N3O2S, and its molecular weight is approximately 295.40 g/mol.

Sumatriptan is a vascular-5HT1 receptor subtype agonist that causes vasoconstriction. It acts on human basilar arteries and helps in relieving migraine headaches.

Sumatriptan Impurities and Synthesis

Sumatriptan forms impurities during its synthetic1 process. These impurities are influenced by reaction conditions, starting materials, and purification techniques. Rigorous quality control measures monitor and remove impurities during synthesis to ensure the safety and efficacy of the final product.

Daicel provides a Certificate of Analysis (CoA) for Sumatriptan impurity standards, including Sumatriptan EP Impurity E, Sumatriptan Impurity 2, Sumatriptan Impurity BP Imp-1/Sumatriptan pyrroloindolium analog, Sumatriptan Impurity-A, Sumatriptan impurity-F, Sumatriptan N-oxide, and Sumatriptan Succinate Impurity. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2,3. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Sumatriptan impurity or degradation product and offer labeled compounds to quantify the efficacy of Sumatriptan. Daicel offers Sumatriptan D6 Format Salt, a deuterium-labeled Sumatriptan compound used in bio-analytical research such as BA/BE studies. We give a complete characterization report on delivery.

References
FAQ's

Frequently Asked Questions

The impurities in Sumatriptan are detected and quantified using various analytical techniques such as Reverse Phase High-Performance Liquid Chromatography (RP-HPLC).

Controlling the presence of impurities in Sumatriptan is crucial for ensuring that the drug is of high quality, safe, and effective. Further, they may harm various aspects of the drug's performance, such as its potency, stability, and overall shelf life.

Water or DMSO is the solvent used in analyzing many impurities in Sumatriptan.

Sumatriptan impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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