General Information

Silodosin Impurities and Silodosin

Daicel Pharma is a reliable source for synthesizing high-quality Silodosin impurities, like

Silodosin Dehydro Impurity, Silodosin Glucuronide -Li salt, Silodosin Nitrile Impurity, etc. These impurities are essential for accurate analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Silodosin. Additionally, Daicel Pharma specializes in the custom synthesis of Silodosin impurities, catering to specific client requirements. These high-quality impurities can be shipped globally, offering convenience and flexibility to customers worldwide.

Silodosin [CAS: 160970-54-7] is a selective alpha-1a adrenergic antagonist that treats the symptoms of benign prostatic hyperplasia (BPH).

Silodosin: Use and Commercial Availability   

Silodosin is a medication primarily used to treat benign prostatic hyperplasia (BPH) symptoms. It helps to improve urine flow and reduce symptoms such as difficulty urinating, weak urine flow, frequent urination, and the urge to urinate urgently. Silodosin helps relieve lower urinary tract symptoms (LUTS) associated with BPH.

Silodosin is available under the brand Rapaflo, which contains the active ingredient, Silodosin.

Silodosin Structure and Mechanism of Action

The chemical name of Silodosin is 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide. Its chemical formula is C₂₅H₃₂F₃N₃O₄, and its molecular weight is approximately 495.5 g/mol.

Silodosin blocks post-synaptic alpha-1 adrenoreceptors causing smooth muscles in the human prostate, bladder base, bladder neck, urethra, and prostatic capsule to relax. It improves urine flow and reduces BPH symptoms.

Silodosin Impurities and Synthesis

During Silodosin’s manufacturing¹, impurities formation is possible and can compromise its effectiveness. These impurities can arise from various sources, including raw materials, intermediates, and chemicals to synthesize Silodosin. Closely managing and monitoring these impurities is paramount to ensure the drug’s optimal efficacy and safety.

Daicel Pharma offers a Certificate of Analysis (CoA) for Silodosin impurity standards, encompassing impurities such as Silodosin Dehydro Impurity, Silodosin Glucuronide -Li salt, Silodosin Nitrile Impurity, among many others. The CoA provides detailed characterization data, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additionally, we give a detailed 13C-DEPT on delivery. With advanced technology and expertise, Daicel can synthesize any unknown Silodosin impurity or degradation product. We also synthesize labeled compounds. Daicel offers deuterium-labeled standards, Silodosin glucuronide-D4, Silodosin-D4, and Silodosin Glucoronide D4 -Li salt for bioanalytical research and BA/BE studies.