Selexipag

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Selexipag – D6

  • CAT Number DCTI-A-070
  • CAS Number 1265295-92-8
  • Molecular Formula C26H26D6N4O4S
  • Molecular Weight 502.66

Selexipag Active metabolite

  • CAT Number DCTI-A-115
  • CAS Number 475085-57-5
  • Molecular Formula C25H29N3O3
  • Molecular Weight 419.53

Selexipag Impurity 1

  • CAT NUMBER DCTI-C-2477
  • CAS NUMBER 2273000-77-2
  • MOLECULAR FORMULA C26H31N3O2
  • MOLECULAR WEIGHT 417.55

Selexipag Impurity 2

  • CAT Number DCTI-C-391
  • CAS Number 2287345-22-4
  • Molecular Formula C27H33N3O3
  • Molecular Weight 447.58

Selexipag Impurity 2

  • CAT NUMBER DCTI-C-2479
  • CAS NUMBER NA
  • MOLECULAR FORMULA C27H35N3O
  • MOLECULAR WEIGHT 417.6

Selexipag Impurity 7

  • CAT NUMBER DCTI-C-2246
  • CAS NUMBER 2273000-76-1
  • MOLECULAR FORMULA C24H27N3O2
  • MOLECULAR WEIGHT 389.5

Selexipag Impurity 8

  • CAT NUMBER DCTI-C-2478
  • CAS NUMBER NA
  • MOLECULAR FORMULA C25H27N3O3
  • MOLECULAR WEIGHT 417.51

Selexipag Impurity A

  • CAT NUMBER DCTI-C-2522
  • CAS NUMBER 475086-75-0
  • MOLECULAR FORMULA C23H27N3O
  • MOLECULAR WEIGHT 361.49

Selexipag Impurity-3

  • CAT Number DCTI-C-635
  • CAS Number 475084-96-9
  • Molecular Formula C29H37N3O3
  • Molecular Weight 475.63
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General Information

Selexipag Impurities and Selexipag 

Daicel Pharma is a reliable source for synthesizing high-quality Selexipag impurities, like Selexipag Active metabolite, Selexipag Impurity 1, Selexipag Impurity 8, and many more. Daicel Pharma offers a range of Selexipag impurities that critically assess active pharmaceutical ingredients’ quality, stability, and safety. Additionally, Daicel Pharma specializes in custom synthesis of Selexipag impurities that meet client requirements. These high-quality impurities can be shipped worldwide, providing flexibility and convenience to customers.

Selexipag [CAS: 475086-01-2] is a member of the class of pyrazine drugs that treat pulmonary arterial hypertension (PAH), delay disease progression, and reduce the risk of hospitalization.

Selexipag: Use and Commercial Availability   

Selexipag is a medication to treat pulmonary arterial hypertension (PAH). Selexipag belongs to a class of drugs called prostacyclin receptor agonists, which work by dilating (widening) the blood vessels in the lungs, reducing the workload on the heart, and improving blood flow. Selexipag delays disease progression and improves survival in patients.

Selexipag is available under Uptravi, which contains the active ingredient, Selexipag.

Selexipag Structure and Mechanism of Action Selexipag Structure and Mechanism of Action

The chemical name of Selexipag is 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide. Its chemical formula is C26H32N4O4S, and its molecular weight is approximately 496.6 g/mol.

Selexipag is a prostacyclin receptor agonist. It hydrolyzes to its potent active metabolite using y carboxylesterase 1.

Selexipag Impurities and Synthesis

During the manufacturing process1 of Selexipag, impurities may form, potentially reducing its effectiveness. They can originate from various sources, including raw materials, intermediates, and chemicals used to synthesize Selexipag. It is necessary to manage and monitor these impurities closely to ensure the drug’s effectiveness and safety.

Daicel provides a comprehensive Certificate of Analysis (CoA) for Selexipag impurity standards, including Selexipag Active metabolite, Selexipag Impurity 1, Selexipag Impurity 8, and more. The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, we give a complete 13C-DEPT. Daicel Pharma possesses the technology and expertise to synthesize any unknown Selexipag impurity or degradation product. We also offer labeled compounds. For bioanalytical research and BA/BE studies, Daicel Pharma supplies Selexipag – D6 and Selexipag Metabolite – D6, deuterium-labeled standards of Selexipag.

References
FAQ's

Frequently Asked Questions

The presence of impurities in Selexipag can significantly affect its quality, safety, and efficacy. Depending on the type and concentration of impurities, they can adversely affect the drug's pharmacological activity and stability and ultimately pose potential risks to patient health. It is, therefore, crucial to carefully manage and control impurities to ensure the drug's optimal performance and safety as a pharmaceutical product.

Selexipag impurities are assessed using analytical techniques such as the novel high-performance liquid chromatography (RP-HPLC) method.

Methanol is the solvent used in analytical techniques to separate and detect Selexipag impurities.

Selexipag Impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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