Saxagliptin

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N-Boc-3,4-dihydroxy-(S)-adamantyl glycine

  • CAT NUMBER DCTI-C-2338
  • CAS NUMBER 681282-72-4
  • MOLECULAR FORMULA C17H27NO6
  • MOLECULAR WEIGHT 341.4

N-Boc-adamatyl glycine

  • CAT NUMBER DCTI-C-2339
  • CAS NUMBER 1334321-39-9
  • MOLECULAR FORMULA C17H27NO5
  • MOLECULAR WEIGHT 325.41

Saxagliptin diastereoisomer-R,S,S,S

  • CAT Number DCTI-C-1583
  • CAS Number 1564265-93-5
  • Molecular Formula C18H25N3O2
  • Molecular Weight 315.42

Saxagliptin diastereoisomer-S,R,S,S

  • CAT Number DCTI-C-1582
  • CAS Number 1564266-00-7
  • Molecular Formula C18H25N3O2
  • Molecular Weight 315.42

Saxagliptin Imine Impurity

  • CAT Number DCTI-C-1242
  • CAS Number 1194836-77-5
  • Molecular Formula C18H25N3O2
  • Molecular Weight 315.42

Saxagliptin isomers-R,R,R,R

  • CAT Number DCTI-C-1581
  • CAS Number 1564265-95-7
  • Molecular Formula C18H25N3O2
  • Molecular Weight 315.41

General Information

Saxagliptin Impurities and Saxagliptin  

Daicel Pharma is a reliable source for synthesizing high-quality Saxagliptin impurities, specifically N-Boc-3,4-dihydroxy-(S)-adamantyl glycine, N-Boc-adamatyl glycine, Saxagliptin diastereoisomer-R, S, S, S, Saxagliptin diastereoisomer-S, R, S, S, Saxagliptin Imine Impurity, and Saxagliptin isomers-R, R, R, R. These impurities aid in evaluating Saxagliptin’s quality, stability, and safety. Daicel Pharma also provides a custom synthesis of Saxagliptin impurity standards that can be shipped anywhere worldwide to meet clients’ requirements.

Saxagliptin [CAS: 361442-04-8] is an oral antidiabetic medication belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. It treats type 2 diabetes mellitus.

Saxagliptin: Use and Commercial Availability   

Saxagliptin is an oral antihyperglycemic agent used to lower blood sugar levels in individuals with type 2 diabetes mellitus. It improves glycemic control with other diabetes medications such as metformin, sulfonylurea, or long- or intermediate-acting insulin (with or without metformin). Saxagliptin helps lower blood sugar levels by increasing the levels of GLP-1 and GIP. Saxagliptin is available under Onglyza.

Saxagliptin Structure and Mechanism of Action Saxagliptin Structure and Mechanism of Action

The chemical name of Saxagliptin is (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Its chemical formula is C18H25N3O2, and its molecular weight is approximately is 315.4 g/mol

Saxagliptin is a DPP4 inhibitor that inactivates incretin hormones. It reduces fasting and postprandial glucose concentrations in patients with type 2 diabetes mellitus.

Saxagliptin Impurities and Synthesis

Saxagliptin’s manufacturing process1 can develop impurities, which could diminish its effectiveness. They may come from various raw materials, intermediates, and chemicals used for Saxagliptin synthesis. It is necessary to manage and monitor these contaminants closely to ensure the drug’s effectiveness and safety.

Daicel Pharma offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Saxagliptin impurity standards such as N-Boc-3,4-dihydroxy-(S)-adamantyl glycine, N-Boc-adamatyl glycine, Saxagliptin diastereoisomer-R, S, S, S, Saxagliptin diastereoisomer-S, R, S, S, Saxagliptin Imine Impurity and Saxagliptin isomers-R, R, R, R, and more. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We also provide 13C-DEPT on request. Upon delivery, we give a complete characterization report. Daicel Pharma has the technology and expertise to prepare any unknown Saxagliptin impurities or degradation products.

References
FAQ's

Frequently Asked Questions

Impurities in Saxagliptin can impact its quality, safety, and efficacy. Depending on the nature and level of impurities, the drug's pharmacological activity and stability may pose risks to the patient's health.

Saxagliptin impurities are detected and quantified using analytical techniques such as high-performance liquid chromatography (HPLC) and the Ultraviolet method.

Water and Methanol are commonly used as a solvent in analytical techniques like high-performance liquid chromatography (HPLC) to separate and detect Saxagliptin impurities.

Saxagliptin Impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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