General Information

Ritonavir Impurities and Ritonavir  

Daicel Pharma provides high-quality Ritonavir impurity standards, which include 2-Chloro NCT Impurity of Ritonavir, Ritonavir 3R-Epimer, Ritonavir Impurity K, Ritonavir Hydroxy Intermediate Impurity, Ritonavir Impurity G, Ritonavir Enantiomer, Ritonavir Impurity-E, Ritonavir EP Impurity L, and more. They are essential for Ritonavir effectiveness, safety, stability, and quality. Daicel Pharma can provide a custom synthesis for Ritonavir impurities and deliver them globally according to client requirements.

Ritonavir [CAS: 155213-67-5] is an L-valine derivative used to treat HIV infection and AIDS.

Ritonavir: Use and Commercial Availability 

Ritonavir is an HIV protease inhibitor. It combines with other antiretroviral agents to treat HIV infection. The drug is available under the tradename of Norvir.

Ritonavir Structure and Mechanism of Action

The chemical name of Ritonavir is (3S,4S,6S,9S)- 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)- 2,7,10,12-Tetraazatridecanoic acid 5-thiazolylmethyl ester. Its chemical formula is C₃₇H₄₈N₆O₅S_2, and its molecular weight is approximately 720.9 g/mol.

Ritonavir inhibits HIV-1 and HIV-2 proteases and leads to the production of non-infectious immature HIV particles.

Ritonavir Impurities and Synthesis

Ritonavir, an antiretroviral medication, may contain impurities impacting its efficacy and safety. Ritonavir impurities include related compounds, process-related, and potential impurities. They can arise from the synthetic process¹, starting materials, or storage conditions. Ritonavir impurities require strict control and monitoring to assure drug safety, efficacy, and quality, and analytical procedures help identify, quantify, and characterize these impurities.

Daicel Pharma offers a Certificate of Analysis (CoA) for Ritonavir impurity standards which include 2-Chloro NCT Impurity of Ritonavir, Ritonavir 3R-Epimer, Ritonavir Impurity K, Ritonavir Hydroxy Intermediate Impurity, Ritonavir Impurity G, Ritonavir Enantiomer, Ritonavir Impurity-E, Ritonavir EP Impurity L, and more. Daicel Pharma’s cGMP-certified analytical laboratory provides this CoA and includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². More characterization details, such as those for 13C-DEPT, are provided on request. Daicel Pharma offers Ritonavir impurities and labeled compounds for testing the efficacy of generic Ritonavir. We can also give Ritonavir-D6, a deuterium-labeled Ritonavir standard for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) studies.