Ritonavir

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2-Chloro NCT Impurity of Ritonavir

  • CAT NUMBER DCTI-C-2545
  • CAS NUMBER 1072830-36-4
  • MOLECULAR FORMULA C11H7ClN2O5S
  • MOLECULAR WEIGHT 314.7

2,5-Thiazolylmethyl dicarbamate Ritonavir

  • CAT Number DCTI-C-1806
  • CAS Number 144142-33-6
  • Molecular Formula C28H30N4O5S2
  • Molecular Weight 566.69

Des-isopropylthiazolyl Ritonavir

  • CAT Number DCTI-C-1061
  • CAS Number 176655-57-5
  • Molecular Formula C30H39N5O5S
  • Molecular Weight 581.73

Hydantoin Aminoalcohol Ritonavir

  • CAT Number DCTI-C-1808
  • CAS Number 1010809-61-6
  • Molecular Formula C29H34N4O5S
  • Molecular Weight 550.67

O-Acyl Ritonavir

  • CAT Number DCTI-C-1809
  • CAS Number NA
  • Molecular Formula C51H69N9O7S3
  • Molecular Weight 1016.34

Ritonavir 3R-Epimer

  • CAT Number DCTI-C-1643
  • CAS Number 1414933-81-5
  • Molecular Formula C37H48N6O5S2
  • Molecular Weight 720.95

Ritonavir 4-hydroxy isomer

  • CAT Number DCTI-C-1810
  • CAS Number NA
  • Molecular Formula C37H48N6O5S2
  • Molecular Weight 720.95

Ritonavir Acetamidoalcohol

  • CAT Number DCTI-C-1807
  • CAS Number 1010808-43-1
  • Molecular Formula C25H29N3O4S
  • Molecular Weight 467.58

Ritonavir Boc-aminoalcohol

  • CAT Number DCTI-C-968
  • CAS Number 162849-95-8
  • Molecular Formula C28H35N3O5S
  • Molecular Weight 525.66
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General Information

Ritonavir Impurities and Ritonavir  

Daicel Pharma provides high-quality Ritonavir impurity standards, which include 2-Chloro NCT Impurity of Ritonavir, Ritonavir 3R-Epimer, Ritonavir Impurity K, Ritonavir Hydroxy Intermediate Impurity, Ritonavir Impurity G, Ritonavir Enantiomer, Ritonavir Impurity-E, Ritonavir EP Impurity L, and more. They are essential for Ritonavir effectiveness, safety, stability, and quality. Daicel Pharma can provide a custom synthesis for Ritonavir impurities and deliver them globally according to client requirements.

Ritonavir [CAS: 155213-67-5] is an L-valine derivative used to treat HIV infection and AIDS.

Ritonavir: Use and Commercial Availability 

Ritonavir is an HIV protease inhibitor. It combines with other antiretroviral agents to treat HIV infection. The drug is available under the tradename of Norvir.

Ritonavir Structure and Mechanism of Action Ritonavir Structure and Mechanism of Action

The chemical name of Ritonavir is (3S,4S,6S,9S)- 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)- 2,7,10,12-Tetraazatridecanoic acid 5-thiazolylmethyl ester. Its chemical formula is C37H48N6O5S2, and its molecular weight is approximately 720.9 g/mol.

Ritonavir inhibits HIV-1 and HIV-2 proteases and leads to the production of non-infectious immature HIV particles.

Ritonavir Impurities and Synthesis

Ritonavir, an antiretroviral medication, may contain impurities impacting its efficacy and safety. Ritonavir impurities include related compounds, process-related, and potential impurities. They can arise from the synthetic process1, starting materials, or storage conditions. Ritonavir impurities require strict control and monitoring to assure drug safety, efficacy, and quality, and analytical procedures help identify, quantify, and characterize these impurities.

Daicel Pharma offers a Certificate of Analysis (CoA) for Ritonavir impurity standards which include 2-Chloro NCT Impurity of Ritonavir, Ritonavir 3R-Epimer, Ritonavir Impurity K, Ritonavir Hydroxy Intermediate Impurity, Ritonavir Impurity G, Ritonavir Enantiomer, Ritonavir Impurity-E, Ritonavir EP Impurity L, and more. Daicel Pharma’s cGMP-certified analytical laboratory provides this CoA and includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. More characterization details, such as those for 13C-DEPT, are provided on request. Daicel Pharma offers Ritonavir impurities and labeled compounds for testing the efficacy of generic Ritonavir. We can also give Ritonavir-D6, a deuterium-labeled Ritonavir standard for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) studies.

References
FAQ's

Frequently Asked Questions

Ritonavir impurities form during the synthetic process from starting materials or as degradation products due to various factors such as reaction conditions, impurities in raw materials, or storage conditions.

Specific acceptance criteria are established for Ritonavir impurities to ensure their levels remain within defined limits and according to regulatory guidelines.

Ritonavir impurities can be related to the quality and efficiency of the drug.

Ritonavir impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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