General Information

Rilpivirine Impurities and Rilpivirine 

Daicel Pharma offers Rilpivirine impurity standards which are Rilpivirine Impurity 2, Rilpivirine Impurity 3, Rilpivirine Impurity 4, Rilpivirine Impurity 6, Rilpivirine Amide Impurity-1, Rilpivirine Amide Impurity-2, Rilpivirine Desmethyl Impurity, Rilpivirine Impurity 6 – Z Isomer, and Rilpivirine Methyl Ester Impurity. These impurities are essential for Rilpivirine quality, effectiveness, safety, and stability. Moreover, Daicel provides a custom synthesis of Rilpivirine impurities and delivers them globally.

Rilpivirine [CAS: 500287-72-9] is an aminopyrimidine that treats HIV infection.

Rilpivirine: Use and Commercial Availability 

Rilpivirine with antiretroviral agents treats HIV-1 infections in antiretroviral treatment-naive patients. This medication is available in the market under the tradename of Edurant.

Rilpivirine Structure and Mechanism of Action

The chemical name of Rilpivirine is 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile. Its chemical formula is C₂₂H₁₈N_6, and its molecular weight is approximately 366.4 g/mol.

Rilpivirine blocks HIV-1 replication by non-competitive inhibition of HIV-1 reverse transcriptase.

Rilpivirine Impurities and Synthesis

Rilpivirine impurities are unexpected chemical substances that could appear during the production¹ or storage of the antiretroviral drug, Rilpivirine. These impurities may come from different sources, such as raw materials, reagents, steps in the process, or degradation products. Rilpivirine impurities require strict control and monitoring to assure drug safety, efficacy, and quality analysis, and analytical procedures help identify, quantify, and characterize these impurities.

Daicel Pharma offers a Certificate of Analysis (CoA) for Rilpivirine impurity standards which are Rilpivirine Impurity 2, Rilpivirine Impurity 3, Rilpivirine Impurity 4, Rilpivirine Impurity 6, Rilpivirine Amide Impurity-1, Rilpivirine Amide Impurity-2, Rilpivirine Desmethyl Impurity, Rilpivirine Impurity 6 – Z Isomer, and Rilpivirine Methyl Ester Impurity. Our cGMP-certified analytical facility provides a comprehensive CoA with detailed characterization data like 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additional characterizations like 13C-DEPT are available upon request. We offer Rilpivirine impurities and degradation products.