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Ribociclib

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RCB-Alkyne Hydroxy Methyl Impurity

  • CAT NUMBER DCTI-C-303
  • CAS NUMBER NA
  • MOLECULAR FORMULA C15H17N3O2
  • MOLECULAR WEIGHT 271.32
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RCB-Chloro dimer impurity

  • CAT NUMBER DCTI-C-328
  • CAS NUMBER NA
  • MOLECULAR FORMULA C24H25ClN6O3
  • MOLECULAR WEIGHT 480.95
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RCB-Cyclopentyl Amine Hydroxy Methyl Impurity

  • CAT NUMBER DCTI-C-302
  • CAS NUMBER NA
  • MOLECULAR FORMULA C17H24N4O
  • MOLECULAR WEIGHT 300.41
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RCB-cyclopentylamine acid impurity

  • CAT NUMBER DCTI-C-304
  • CAS NUMBER NA
  • MOLECULAR FORMULA C17H22N4O2
  • MOLECULAR WEIGHT 314.39
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RCB-N-Oxide Impurity

  • CAT NUMBER DCTI-C-459
  • CAS NUMBER NA
  • MOLECULAR FORMULA C23H30N8O2
  • MOLECULAR WEIGHT 450.55
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Ribociclib Piperizine Impurity

  • CAT NUMBER DCTI-C-2767
  • CAS NUMBER NA
  • MOLECULAR FORMULA C18H26N6O (Free Base); C18H27ClN6O (HCl Salt)
  • MOLECULAR WEIGHT 342.45 (Free Base); 378.91 (HCl Salt)
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Ribociclib Labelled Standard
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Ribociclib-D8

  • CAT Number DCTI-A-248
  • CAS Number 2167898-24-8
  • Molecular Formula C23H22D8N8O
  • Molecular Weight 442.6
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Triphenyl Iso-Propyl Ether Impurity

  • CAT NUMBER DCTI-C-2068
  • CAS NUMBER 13594-78-0
  • MOLECULAR FORMULA C22H22O
  • MOLECULAR WEIGHT 302.42
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References
FAQ's

References

  1. Besong, Gilbert; Brain, Christopher Thomas; Brooks, Clinton A.; Congreve, Miles Stuart; Dagostin, Claudio; He, Guo; Hou, Ying; Howard, Steven; Li, Yue; Lu, Yipin; et al, Pyrrolopyrimidine Compounds as CDK inhibitors, Novartis AG; Astex Therapeutics Ltd., Switzerland, EP2331547B1, July 30. 2014
  2. Bao, Xun; Wu, Jianmei; Sanai, Nader; Li, Jing, Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, Volume: 166, Pages: 197-204, 2019

Frequently Asked Questions

Ribociclib impurities are detected and analyzed using analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS).

There are specific Ribociclib impurities of particular concern due to their potential impact on patient safety.

Measures such as careful selection of starting materials, optimization of reaction conditions, and implementation of purification techniques help control and minimize the presence of Ribociclib impurities during its synthetic process.

Ribociclib impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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