Remdesivir

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(R)-Tri O-benzyl nitrile Impurity

  • CAT Number DCTI-C-930
  • CAS Number 1355357-49-1
  • Molecular Formula C33H31N5O4
  • Molecular Weight 561.64

(S)-Tri-O-Benzyl Nitrile Impurity

  • CAT Number DCTI-C-931
  • CAS Number 1369903-46-7
  • Molecular Formula C33H31N5O4
  • Molecular Weight 561.64

1-Amino-1H-pyrrole-2-carbonitrile

  • CAT Number DCTI-C-1507
  • CAS Number 159326-66-6
  • Molecular Formula C5H5N3
  • Molecular Weight 107.12

2-butyl ((S)-(perfluorophenoxy) (phenoxy) phosphoryl)-L-alaninate

  • CAT Number DCTI-C-1172
  • CAS Number 1673560-27-4
  • Molecular Formula C19H19F5NO5P
  • Molecular Weight 467.33

2-ethylbutyl ((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)-D-alaninate

  • CAT Number DCTI-C-975
  • CAS Number NA
  • Molecular Formula C21H27N2O7P
  • Molecular Weight 450.43

2-ethylbutyl ((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-D-alaninate

  • CAT Number DCTI-C-976
  • CAS Number NA
  • Molecular Formula C21H27N2O7P
  • Molecular Weight 450.43

2-ethylbutyl D-alaninate hydrochloride

  • CAT Number DCTI-C-941
  • CAS Number 2096981-79-0
  • Molecular Formula C9H19NO2 (Free Base) C9H20ClNO2 (Salt
  • Molecular Weight 173.26 (Free Base) 209.71 (Salt)

2-ethylbutyl L-alaninate hydrochloride

  • CAT Number DCTI-C-942
  • CAS Number 946511-97-3
  • Molecular Formula C9H19NO2 (Free Base) C9H20ClNO2 (HCl Salt)
  • Molecular Weight 173.26 (Free Base) 209.71 (HCl Salt)

7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine

  • CAT Number DCTI-C-1513
  • CAS Number 1770840-43-1
  • Molecular Formula C6H5IN4
  • Molecular Weight 259.96
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General Information

Remdesivir Impurities and Remdesivir  

Daicel Pharma offers high-quality Remdesivir impurity standards, (R)-Tri O-benzyl nitrile Impurity, N-Butyl (SRR) Remdesivir, RDV pentafluoro RR isomer, Remdesivir Impurity- 1, Remdesivir Impurity 8, Remdesivir Impurity C, Remdesivir Impurity- 18, Remdesivir Impurity 14, Remdesivir R-P D-Alanine isomer, Remdesivir- S-Isomer at CN, and more. The effectiveness, stability, safety, and quality analysis of Remdesivir depends on these impurities. Daicel Pharma offers custom synthesis for Remdesivir impurities and delivers them internationally.

Remdesivir [CAS: 1809249-37-3] is an antiviral medication for treating RNA virus infections. It is a SARS-CoV-2 nucleotide analog RNA polymerase inhibitor.

Remdesivir: Use and Commercial Availability 

Remdesivir treats mild-to-moderate COVID-19 patients at high risk of severe COVID-19, including hospitalization or death.

This medication is available under the brand name Veklury.

Remdesivir Structure and Mechanism of Action Remdesivir Structure and Mechanism of Action

The chemical name of Remdesivir is (S)-2-Ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate. Its chemical formula is C27H35N6O8P, and its molecular weight is approximately 602.6 g/mol.

Remdesivir inhibits the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and blocks viral RNA synthesis.

Remdesivir Impurities and Synthesis

Remdesivir impurities are unintended chemical compounds present during the synthesis1 or storage of Remdesivir, an antiviral medication for treating viral infections such as COVID-19. These impurities can arise from various sources, including starting materials, reagents, intermediates, or degradation products.

Daicel Pharma offers a Certificate of Analysis (CoA) for Remdesivir impurity standards that involve (R)-Tri O-benzyl nitrile Impurity, N-Butyl (SRR) Remdesivir, RDV pentafluoro RR isomer, Remdesivir Impurity- 1, Remdesivir Impurity 8, Remdesivir Impurity C, Remdesivir Impurity- 18, Remdesivir Impurity 14, Remdesivir R-P D-Alanine isomer, Remdesivir- S-Isomer at CN, and more. Our cGMP-certified analytical laboratory provides CoA with detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. More characterization details, such as those for 13C-DEPT, can be provided on request. Daicel Pharma specializes in synthesizing Remdesivir impurities and degradation products.

References
FAQ's

Frequently Asked Questions

The potential sources of Remdesivir impurities in the synthetic process include starting materials, reagents, intermediates, and degradation products.

Remdesivir impurities are managed during the storing and distribution process through strict quality control measures, proper storage conditions, and adherence to regulatory guidelines to ensure drug integrity, purity, and stability.

Yes, impurities in Remdesivir are evaluated during clinical trials to ensure the safety and efficacy of the medication.

Remdesivir impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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