General Information

Regadenoson Impurities and Regadenoson 

Daicel Pharma synthesizes Regadenoson impurity standards such as Regadenoson Impurity-7, Regadenoson Impurity-2, Regadenoson impurity C, Regadenoson impurity A, Regadenoson impurity D, and Regadenoson Carboxylic Acid impurity. These impurities are essential for Regadenoson quality, effectiveness, safety, and stability. Furthermore, Daicel Pharma synthesizes custom Regadenoson impurities and delivers them globally.

Regadenoson [CAS: 313348-27-5] is an adenosine receptor agonist. It helps in coronary vasodilation and myocardial perfusion imaging.

Regadenoson: Use and Commercial Availability 

Regadenoson anhydrous is a Cardiac Stress Test Agent in Pharmacology. It is for diagnostic purposes. Rapiscan contains the active substance, Regadenoson, a selective coronary vasodilator. It is a stress agent for radionuclide myocardial perfusion imaging (MPI) for adult patients unable to undergo appropriate exercise stress. This drug is available under the tradename of Lexiscan.

Regadenoson Structure and Mechanism of Action

The chemical name of Regadenoson is 2-[4-[(Methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine. Its chemical formula is C₁₅H₁₈N₈O₅, and its molecular weight is approximately 390.35 g/mol.

Regadenoson activates the A_2A adenosine receptor, causes coronary vasodilation, and raises coronary blood flow (CBF).

Regadenoson Impurities and Synthesis

Regadenoson impurities are chemical compounds that form unintentionally during the production¹ or storage of Regadenoson, a medicine used for cardiac stress testing. These impurities might come from raw materials, reagents, intermediates, or degradation products. Regadenoson impurities require strict control and monitoring to assure drug safety, efficacy, and quality, and analytical procedures help identify, quantify, and characterize these impurities.

Daicel Pharma offers a Certificate of Analysis (CoA) for Regadenoson impurity standards Regadenoson impurities such as Regadenoson Impurity-7, Regadenoson Impurity-2, Regadenoson impurity C, Regadenoson impurity A, Regadenoson impurity D, and Regadenoson Carboxylic Acid impurity. Our cGMP-certified analytical laboratory provides Daicel Pharma’s CoA and includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². More characterization details, such as those for 13C-DEPT, can be provided on request. Daicel Pharma specializes in synthesizing Regadenoson impurities and degradation compounds.