General Information

Propofol Impurities and Propofol

Daicel Pharma offers Propofol impurity standards, which include Propofol EP impurity-K, Propofol EP impurity-L, and Propofol EP impurity-O. Their presence can influence the effectiveness, stability, and safety of Propofol. Daicel Pharma offers custom synthesis for Propofol impurities and provides international delivery.

Propofol [CAS: 2078-54-8] is a phenol that acts as an anesthetic and for managing refractory status epilepticus.

Propofol: Use and Commercial Availability 

Propofol is an anesthetic drug that is injected intravenously during general anesthesia. It acts as a sedative and an anticonvulsant. It also keeps patients in a coma in critical care units (ICUs). This drug is available under tradenames such as Diprivan.

Propofol Structure and Mechanism of Action

The chemical name of Propofol is 2,6-Bis(1-methylethyl)phenol. Its chemical formula is C₁₂H₁₈O, and its molecular weight is approximately 178.27 g/mol.

Propofol inhibits the functioning of the neurotransmitter gamma-aminobutyric acid (GABA).

Propofol Impurities and Synthesis

Impurities in Propofol are unwanted chemicals present as unexpected byproducts of the synthetic¹ process, or they get introduced during production or storage. These impurities may influence the drug’s quality, safety, and efficacy.

Daicel Pharma offers a Certificate of Analysis (CoA) for Propofol impurity standards such as Propofol EP impurity-K, Propofol EP impurity-L, and Propofol EP impurity-O, from an analytical facility that is cGMP-compliant. Daicel Pharma provides a CoA with comprehensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additional characterization details, including 13C-DEPT, can be provided upon request. At Daicel Pharma, our team of experts can provide impurities and labeled compounds of Propofol to assess generic Propofol.