Primaquine

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(N3-(6-METHOXYQUINOLIN-8-YL) PENTANE-1,3-DIAMINE)

  • CAT NUMBER DCTI-C-2459
  • CAS NUMBER 2732404-25-8
  • MOLECULAR FORMULA C15H21N3O
  • MOLECULAR WEIGHT 259.35

PRIMAQUINE PHOSPHATE IMPURITY

  • CAT NUMBER DCTI-C-2830
  • CAS NUMBER NA
  • MOLECULAR FORMULA C13H13NO2
  • MOLECULAR WEIGHT 215.25

General Information

Primaquine Impurities and Primaquine

Daicel Pharma offers Primaquine impurity standards, including Primaquine Phosphate Impurity and (N3-(6-Methoxyquinolin-8-Yl) Pentane-1,3-Diamine). Their presence can have an impact on the efficacy, quality, and safety of Primaquine. Daicel Pharma custom prepares Primaquine impurities and delivers them globally.

Primaquine [CAS: 90-34-6] is an aminoquinoline compound that treats malaria and Pneumocystis pneumonia, primarily functioning as an antimalarial agent.

Primaquine: Use and Commercial Availability

Primaquine plays a crucial role as an antimalarial agent and prevents malaria relapse. Among the known 8-aminoquinolines, Primaquine treats extracellular forms of malaria from infections caused by P. vivax and P. ovale parasites. This drug is available under Avlon, etc.

Primaquine Structure and Mechanism of ActionPrimaquine Structure and Mechanism of Action 

The chemical name of Primaquine is N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine. Its chemical formula is C15H21N3O, and its molecular weight is approximately 259.35 g/mol.

The exact mechanism of action of Primaquine is not known.

Primaquine Impurities and Synthesis 

Primaquine impurities are undesired compounds found in Primaquine formulations that can occur during the synthetic process1 or be introduced during manufacture or storage. They can impair Primaquine’s quality, safety, and efficacy. As a result, stringent controls are put in place to identify, characterize, and manage impurities within permissible ranges.

Daicel Pharma offers a Certificate of Analysis (CoA) for Primaquine impurity standards, including Primaquine Phosphate Impurity and (N3-(6-Methoxyquinolin-8-Yl) Pentane-1,3-Diamine). Our analytical facility, certified under current Good Manufacturing Practices (cGMP), provides a comprehensive CoA with detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional characterization details like 13C-DEPT on request. Our experienced team at Daicel Pharma specializes in synthesizing Primaquine impurities.

References
FAQ's

Frequently Asked Questions

The presence of impurities in Primaquine is not necessarily limited to specific formulations or dosage forms, as it depends on various factors such as manufacturing processes and quality control measures implemented by different manufacturers.

Yes, impurities in Primaquine can undergo transformation or degradation over time, potentially resulting in new impurity formation.

To ensure the purity and quality of Primaquine impurities during storage and distribution, appropriate packaging materials, storage conditions, and quality control processes are implemented to prevent contamination and degradation and maintain product integrity.

Primaquine impurities are stored preferably at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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