General Information

Pentoxifylline Impurities and Pentoxifylline

Daicel Pharma offers Pentoxifylline impurity standards like Pentoxifylline Metabolite V and Pentoxifylline Metabolite I. The impurities can impact Pentoxifylline efficacy, stability, and safety. Daicel Pharma can synthesize Pentoxifylline impurities and deliver them worldwide.

Pentoxifylline [CAS: 6493-05-6] is a synthetic compound derived from dimethylxanthine that modifies blood flow while possessing both anti-oxidant and anti-inflammatory properties. It treats symptoms of intermittent claudication due to peripheral arterial disease.

Pentoxifylline: Use and Commercial Availability

Pentoxifylline treats patients with chronic occlusive artery disease who have intermittent claudication. It may enhance limb function and lessen discomfort but cannot replace other treatments, such as surgical bypass surgery. Pentoxifylline, a xanthine derivative, reduces blood viscosity. This medication is available under certain tradenames such as Pentoxil and Trental.

Pentoxifylline Structure and Mechanism of Action

The chemical name of Pentoxifylline is 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione. Its chemical formula is C₁₃H₁₈N₄O₃, and its molecular weight is approximately 278.31 g/mol.

Pentoxifylline decreases the viscosity of blood and improves blood flow properties.

Pentoxifylline Impurities and Synthesis

Impurities in Pentoxifylline can develop at several stages of the synthetic process¹, such as incomplete reactions, side reactions, and contaminants in the raw materials and reagents. Depending on the individual impurity and the circumstances, different Pentoxifylline impurities can synthesize using methods.

Daicel Pharma offers a Certificate of Analysis (CoA) for Pentoxifylline impurity standards, such as Pentoxifylline Metabolite V and Pentoxifylline Metabolite I. We provide a Certificate of Analysis (CoA) from our cGMP-certified analytical lab, which includes extensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additional characterization information, including 13C-DEPT, can be provided upon request. Our team at Daicel Pharma specializes in offering Pentoxifylline impurities and degradation products. We offer Pentoxifylline Metabolite V-d6, Pentoxifylline Metabolite I-D6, 7-(Methyl-D3)-Xanthine, and 1,3,7- Trimethylxanthine-d3, highly pure deuterium-labeled Pentoxifylline compounds, valuable for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) researches.