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Macitentan

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N-[5-(4-bromophenyl)-6-{2-[(5-chloropyrimidin-2-yl...

  • CAT NUMBER DCTI-C-2128
  • CAS NUMBER 2443747-63-3
  • MOLECULAR FORMULA C19H20BrClN6O4S
  • MOLECULAR WEIGHT 543.82
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Macitentan-DCTI-C-028-Daicel
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N-Despropyl Macitentan

  • CAT Number DCTI-C-028
  • CAS Number 1103522-45-7
  • Molecular Formula C16H14Br2N6O4S
  • Molecular Weight 546.19
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O-Desbromo-pyrimidinyl Macitentan

  • CAT NUMBER DCTI-C-3255
  • CAS NUMBER 1393813-43-8
  • MOLECULAR FORMULA C15H19BrN4O4S
  • MOLECULAR WEIGHT 431.3
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References
FAQ's

References

  1. Bolli, Martin; Boss, Christoph; Fischli, Walter; Clozel, Martine; Weller, Thomas, Novel Sulfamides and Their Use As Endothelin Receptor Antagonists, Actelion Pharmaceuticals Ltd., Switzerland, EP1345920B1, April 12, 2006
  2. Yu, Lixiu ; Zhou, Ying; He, Xiaomeng; Li, Huqun; Chen, Hui; Li, Weiyong, Simultaneous determination of macitentan and its active metabolite in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Volume: 1002, Pages: 358-363, 2015
 

Frequently Asked Questions

Regulatory authorities require manufacturers to report and document the presence of impurities in Macitentan formulations, including their identification, quantification, and compliance with specified limits.

Some impurities in Macitentan can contribute to changes in color, odor, or taste. Strict control measures are in place to ensure the product's organoleptic properties remain within acceptable limits.

Acetonitrile is the solvent used when analyzing many impurities in Macitentan.

Macitentan impurities should be stored, at a controlled room temperature, usually between 2-8 °C.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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