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Ibrutinib

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Ibrutinib-DCTI-C-792-Daicel
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Ibrutinib chloro impurity

  • CAT Number DCTI-C-792
  • CAS Number 1288338-96-4
  • Molecular Formula C25H25ClN6O2
  • Molecular Weight 476.97
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Ibrutinib-DCTI-A-066-Daicel
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Ibrutinib Metabolite-PCI-45227

  • CAT Number DCTI-A-066
  • CAS Number 1654820-87-7
  • Molecular Formula C25H26N6O4
  • Molecular Weight 474.51
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Ibrutinib-DCTI-C-067-Daicel
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Ibrutinib Metabolite-PCI-45227 – D5

  • CAT Number DCTI-A-067
  • CAS Number 1226872-27-0(Unlabelled)
  • Molecular Formula C25H21D5N6O4
  • Molecular Weight 479.55
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Ibrutinib-DCTI-C-360-Daicel
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Ibrutinib methoxy impurity

  • CAT Number DCTI-C-360
  • CAS Number 2031255-26-0
  • Molecular Formula C26H28N6O3
  • Molecular Weight 472.55
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Ibrutinib-DCTI-A-057-Daicel
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Ibrutinib-D5

  • CAT Number DCTI-A-057
  • CAS Number 1553977-17-5
  • Molecular Formula C25H19D5N6O2
  • Molecular Weight 445.54
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Ibrutinib-DCTI-C-817-Daicel
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IBT6A adduct

  • CAT Number DCTI-C-817
  • CAS Number 2064175-43-3
  • Molecular Formula C40H35N6OP
  • Molecular Weight 646.73
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Ibrutinib-DCTI-C-818-Daicel
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IBT7A adduct

  • CAT Number DCTI-C-818
  • CAS Number 2064175-44-4
  • Molecular Formula C43H37N6O2P
  • Molecular Weight 700.78
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Methyl (R)-3-((1-(1acryloylpiperidin-3-yl)-3-(4phe...

  • CAT NUMBER DCTI-C-2713
  • CAS NUMBER NA
  • MOLECULAR FORMULA C29H30N6O4
  • MOLECULAR WEIGHT 526.6
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References
FAQ's

References

  1. Honigberg, Lee; Verner, Erik; Pan, Zhengying, “Inhibitors of bruton's tyrosine kinase”, Pharmacyclics, Inc., United States, US7514444B2, April 7, 2009
  2. Konduru, Naresh; Gundla, Rambabu; Katari, Naresh Kumar; Paidikondala, Kalyani; Reddy, Annem Siva; Jagadabi, Varaprasad, “Development and Validation of a Stability-indicating Method for Ibrutinib: Identification and Separation of Degradation Products, Known and Genotoxic Impurities Using RP-HPLC/PDA and QDa Mass Detectors”, Analytical Chemistry Letters, Volume: 10, Issue: 1, Pages: 113-136, 2020
  3. Rood, Johannes J. M. ; van Hoppe, Stephanie; Schinkel, Alfred H.; Schellens, Jan H. M.; Beijnen, Jos H.; Sparidans, Rolf W.,” Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies”, Journal of Pharmaceutical and Biomedical Analysis, Volume: 118, Pages: 123-131, 2016

Frequently Asked Questions

Isomeric impurities in Ibrutinib occur due to the presence of stereoisomers during the synthetic process.

Degradant impurities in Ibrutinib result from the breakdown of the drug substance due to factors such as hydrolysis, oxidation, or photolysis.

The residual solvents in Ibrutinib are the solvents used during the synthetic process but remain in the final product in small amounts.

The impurities in Ibrutinib are identified and characterized through analytical methods such as liquid chromatography-mass spectrometry (LC-MS), etc.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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