Hydrocortisone

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17-Keto Hydroxyprogesteron

  • CAT Number DCTI-C-1752
  • CAS Number 382-44-5
  • Molecular Formula C19H26O3
  • Molecular Weight 302.41

Cortisone 17-Carboxylic Acid

  • CAT NUMBER DCTI-C-1988
  • CAS NUMBER 3597-44-2
  • MOLECULAR FORMULA C20H26O5
  • MOLECULAR WEIGHT 346.42

Delta-9,11-Hydrocortisone Hemisuccinate

  • CAT NUMBER DCTI-C-2441
  • CAS NUMBER 103497-66-1
  • MOLECULAR FORMULA C25H32O7
  • MOLECULAR WEIGHT 444.52

Hydrocortisone (9B, 11B – Epoxide)

  • CAT Number DCTI-C-1123
  • CAS Number 10072-97-6
  • Molecular Formula C21H28O5
  • Molecular Weight 360.45

Hydrocortisone 17-Formoxyl Impurity

  • CAT NUMBER DCTI-C-2046
  • CAS NUMBER NA
  • MOLECULAR FORMULA C21H28O6
  • MOLECULAR WEIGHT 376.45
Hydrocortisone-DCTI-C-1277-Daicel
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Hydrocortisone E-enol aldehyde

  • CAT Number DCTI-C-1277
  • CAS Number 105562-12-7
  • Molecular Formula C21H28O4
  • Molecular Weight 344.45

Hydrocortisone EP Imp-N (Symmetrical dimer)

  • CAT Number DCTI-C-1032
  • CAS Number NA
  • Molecular Formula C42H58O10
  • Molecular Weight 722.92

Hydrocortisone EP Impurity K

  • CAT NUMBER DCTI-C-2047
  • CAS NUMBER 640-87-9
  • MOLECULAR FORMULA C23H32O5
  • MOLECULAR WEIGHT 388.5

Hydrocortisone glyoxal hydrate Isomer-2

  • CAT NUMBER DCTI-C-2510
  • CAS NUMBER 1960421-03-7
  • MOLECULAR FORMULA C21H30O5
  • MOLECULAR WEIGHT 362.47
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General Information

Hydrocortisone Impurities and Hydrocortisone

Daicel Pharma synthesizes more than ten high-quality Hydrocortisone impurities such as Keto Hydroxyprogesteron-17, Cortisone 17-Carboxylic Acid, Hydrocortisone (9B, 11B – Epoxide), Hydrocortisone 17-Formoxyl Impurity, Hydrocortisone E-enol aldehyde, Hydrocortisone Z-enol aldehyde, Hydrocortisone-20-acid and more, crucial in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient, Hydrocortisone. Moreover, Daicel Pharma offers custom synthesis of Hydrocortisone impurities and delivers them globally.

Hydrocortisone [CAS: 50-23-7] is a medicine similar in chemical structure to the natural hormone produced by the adrenal glands. It is a synthetic or semisynthetic analog of the natural hydrocortisone hormone. It helps treat various medical conditions, including immune system dysfunction, cancer, inflammation, etc.

Hydrocortisone: Use and Commercial Availability

Hydrocortisone is a versatile medication treating various medical conditions affecting collagen, endocrine, allergic, rheumatic, hematologic, respiratory, gastrointestinal, neoplastic, ophthalmic, etc. Based on the patient’s condition Hydrocortisone is available in various forms, including tablets, enemas, topical ointments with antibiotics, and topical creams with acyclovir for cold sores. Hydrocortisone is marketed under different brand names worldwide, including Cortef, Solu-Cortef, and Hydrocortone.

Hydrocortisone Structure and Mechanism of Action Hydrocortisone Structure and Mechanism of Action

The chemical name of Hydrocortisone is 11β,17,21-Trihydroxypregn-4-ene-3,20-dione. Its chemical formula is C21H30O5, and its molecular weight is approximately 362.5g/mol.

Hydrocortisone inhibits the accumulation of inflammatory cells at inflammation sites. It binds to glucocorticoid receptors and inhibits inflammatory transcription factors.

Hydrocortisone Impurities and Synthesis

When Hydrocortisone is manufactured1, impurities2 may form substances that may potentially harm patients. Some impurities that can develop include 11- epimers and degradation products generated from hydrolysis or oxidation. It is necessary to monitor impurity levels in Hydrocortisone to maintain its safety and effectiveness in treating patients.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Hydrocortisone impurity standards, including Keto Hydroxyprogesteron-17, Cortisone 17-Carboxylic Acid, Hydrocortisone (9B, 11B – Epoxide), Hydrocortisone 17-Formoxyl Impurity, Hydrocortisone E-enol aldehyde, Hydrocortisone Z-enol aldehyde, Hydrocortisone-20-acid and so on. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We also provide 13C-DEPT and CHN on request. We give a complete characterization report on delivery.

Daicel has the technology and expertise to prepare any unknown Hydrocortisone impurity or degradation product. We also provide labeled compounds to quantify the efficacy of generic Hydrocortisone. Daicel offers highly pure isotope-labeled standards of Hydrocortisone for bioanalytical research and BA/BE studies with isotope data in CoA.

References
FAQ's

Frequently Asked Questions

Analytical methods such as high-performance liquid chromatography (HPLC) help identify and quantify Hydrocortisone impurities.

Purification methods involving chromatography remove impurities from  Hydrocortisone             .

Some sources of Hydrocortisone impurities include starting materials, intermediates, and degradation products.

Hydrocortisone impurities may cause harm to humans if they have high toxicity levels.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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