General Information

Frovatriptan Impurities and Frovatriptan

Daicel Pharma specializes in synthesizing impurities for Frovatriptan, an active pharmaceutical ingredient. We offer impurities such as 1-(R)-Hydroxy Frovatriptan and 1-(S)-Hydroxy Frovatriptan, which play a vital role in evaluating the purity and safety of Frovatriptan. Daicel Pharma also provides custom synthesis of Frovatriptan impurities to meet specific client needs and offer worldwide delivery options.

Frovatriptan [CAS: 158747-02-5] is a medication, a second-generation member of triptans, and functions as a selective agonist of the serotonin 5-HT1B/D receptor. It has a similar action to sumatriptan, the initial triptan and representative of this class. Frovatriptan gives immediate relief from migraine attacks.

Frovatriptan: Use and Commercial Availability  

Frovatriptan, sold under Frova, is a triptan medication for treating migraine headaches, particularly those associated with menstruation. It causes vasoconstriction of the arteries and veins that supply blood to the head. Frovatriptan helps in the short-term prevention of menstrual migraine.

Frovatriptan Structure and Mechanism of Action

The chemical name of Frovatriptan is (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide. Its chemical formula is C₁₄H₁₇N₃O, and its molecular weight is approximately 243.30 g/mol.

Frovatriptan binds with 5-HT_1B and 5-HT_1D receptors and inhibits excess dilation of the extracerebral and intracranial arteries.

Frovatriptan Impurities and Synthesis

Impurities in Frovatriptan are unintended substances that may be present in the drug product, apart from the intended active ingredient. They can arise from various sources such as raw materials, manufacturing processes¹, or degradation of Frovatriptan over time. Examples of impurities in Frovatriptan can include related compounds, residual solvents, degradation products, or impurities introduced during synthesis. Controlling and monitoring impurities in Frovatriptan is crucial to ensure the safety and quality of the medication.

Daicel Pharma, in adherence to cGMP standards, operates an analytical facility where we prepare Frovatriptan impurity standards like 1-(R)-Hydroxy Frovatriptan and 1-(S)-Hydroxy Frovatriptan. We offer a comprehensive Certificate of Analysis (CoA) for these impurities, providing a detailed characterization report. The CoA includes data obtained through techniques, 1H NMR, 13C NMR, IR, MASS, and HPLC purity analysis². Upon request, we provide additional data like 13C-DEPT. We can synthesize unknown Frovatriptan impurities or degradation products. Each delivery has a comprehensive characterization report.