General Information

Fluvoxamine Impurities and Fluvoxamine

Daicel Pharma specializes in synthesizing impurities for Fluvoxamine, an active pharmaceutical ingredient. We offer impurities such as Fluvoxamine acid N-Acetyl Impurity, Fluvoxamine EP impurity I, Fluvoxamine EP impurity J, Fluvoxethanol, and Fluvoxketone, which play a vital role in evaluating the purity and safety of Fluvoxamine. Daicel Pharma also provides custom synthesis of Fluvoxamine impurities to meet specific client needs and offer worldwide delivery options.

Fluvoxamine [CAS: 54739-18-3] is an antidepressant, anxiolytic drug, and selective serotonin reuptake inhibitor (SSRI). It treats obsessive-compulsive disorder (OCD) and various anxiety disorders. Fluvoxamine is exerts its therapeutic effects by inhibiting the reuptake of serotonin, a neurotransmitter involved in regulating mood and anxiety. By increasing serotonin levels in the brain, Fluvoxamine helps alleviate symptoms associated with depression, OCD, and anxiety disorders.

Fluvoxamine: Use and Commercial Availability  

Fluvoxamine, available under Luvox and Luvox CR, is an SSRI medication for treating OCD, social anxiety disorder, and major depression. Although it is less common than other SSRIs, it is highly effective in managing anxiety disorders. Furthermore, it treats bulimia nervosa.

Fluvoxamine Structure and Mechanism of Action

The chemical name of Fluvoxamine is (1E)- 5-methoxy-1-[4-(trifluoromethyl)phenyl]- O-(2-aminoethyl)oxime 1-Pentanone. Its chemical formula is C₁₅H₂₁F₃N₂O_2, and its molecular weight is approximately 318.34 g/mol.

The mechanism of action of Fluvoxamine is due to serotonin reuptake inhibition in the brain neurons.

Fluvoxamine Impurities and Synthesis

Fluvoxamine, an antidepressant and anxiolytic medication, may contain impurities that can from various sources. They occur during the manufacturing process¹, degradation over time, or as residual solvents. Common Fluvoxamine impurities include related substances, degradation products, and residual solvents. They can affect the drug’s stability, potency, and overall quality. Therefore, strict quality control measures during the manufacturing process minimize impurity levels and ensure the purity of the final product.

Daicel Pharma, in adherence to cGMP standards, operates an analytical facility where we prepare Fluvoxamine impurity standards like Fluvoxamine acid N-Acetyl Impurity, Fluvoxamine EP impurity I, Fluvoxamine EP impurity J, Fluvoxethanol, and Fluvoxketone. We offer a comprehensive Certificate of Analysis (CoA) for these impurities, providing a detailed characterization report. The CoA includes data obtained through techniques, 1H NMR, 13C NMR, IR, MASS, and HPLC purity analysis². Upon request, we give additional data like 13C-DEPT. We can synthesize unknown Fluvoxamine impurities or degradation products. Each delivery has a comprehensive characterization report.