General Information

Desogestrel Impurities and Desogestrel 

Daicel Pharma synthesizes high-quality Desogestrel impurities, such as Desogestrel Impurity A, Desogestrel Impurity B, Desogestrel Impurity C, Desogestrel impurity D, and Desogestrel impurity E, crucial   in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient, Desogestrel. Moreover, Daicel Pharma offers custom synthesis of Desogestrel impurities and delivers them globally.

Desogestrel [CAS: 54024-22-5] is a synthetic progestogen similar in structure to levonorgestrel. It activates progesterone hormone receptors. It acts as a contraceptive and a    hormone replacementtherapy.

Desogestrel: Use and Commercial Availability

Desogestrel is available in combination with ethinyl estradiol in the US as an oral contraceptive. However, it is sold under various brand names globally, such as Bekyree, Cyclessa, Desogen, Emoquette, Enskyce, Isibloom, Kalliga, Kariva, Kimidess, Mircette, Ortho-Cept, Pimtrea, Simliya, Velivet, Viorele, Volnea, among others.

Desogestrel Structure and Mechanism of Action

The chemical structure of Desogestrel is 13-Ethyl-11-methylene-18,19-dinor-17α-4-pregnen-20-yn-17-ol. Its chemical formula is C₂₂H₃₀O, and its molecular weight is approximately 310.5g/mol.

Desogestrel inhibits ovulation. It causes changes in cervical mucus that prevents sperm entry into the uterus. Further, changes in the endometrium reduce the likelihood of implantation. Oral contraceptives suppress gonadotropins.

Desogestrel Impurities and Synthesis

During the manufacturing process¹, impurities may form in Desogestrel due to various reasons such as incomplete reactions, side reactions, degradation, and contamination. The presence of these impurities in Desogestrel can affect its efficacy and safety. Therefore, control of impurity formation and their levels in the final product is essential.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Desogestrel impurity standards, including Desogestrel Impurity A, Desogestrel Impurity B, Desogestrel Impurity C, Desogestrel impurity D, and Desogestrel impurity E. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We    also provide 13C-DEPT and CHN on request. We also give a complete characterization report. Daicel has the technology and expertise to prepare any unknown Desogestrel impurity or degradation product. Daicel also provides labeled compounds³ to quantify the efficacy of generic Desogestrel. Daicel offers highly pure isotope-labeled standards of Desogestrel for bioanalytical research and BA/BE studies with isotope data in CoA.