Cytidine

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Cytidine 2-Ethylbutyl Impurity (R-Isomer)

  • CAT NUMBER DCTI-C-1990
  • CAS NUMBER NA
  • MOLECULAR FORMULA C24H35N4O10P
  • MOLECULAR WEIGHT 570.54

Cytidine 2-Ethylbutyl Impurity (S-Isomer)

  • CAT NUMBER DCTI-C-1992
  • CAS NUMBER NA
  • MOLECULAR FORMULA C24H35N4O10P
  • MOLECULAR WEIGHT 570.54

Cytidine 2-Ethylbutyl Sesamol Impurity (R-Isomer)

  • CAT NUMBER DCTI-C-1991
  • CAS NUMBER NA
  • MOLECULAR FORMULA C25H35N4O12P
  • MOLECULAR WEIGHT 614.54

Cytidine 2-Ethylbutyl sesamol Impurity (S-Isomer)

  • CAT NUMBER DCTI-C-1993
  • CAS NUMBER NA
  • MOLECULAR FORMULA C25H35N4O12P
  • MOLECULAR WEIGHT 614.54

Cytidine Isopropyl Impurity

  • CAT NUMBER DCTI-C-1989
  • CAS NUMBER NA
  • MOLECULAR FORMULA C21H29N4O10P
  • MOLECULAR WEIGHT 528.45

Cytidine Isopropyl Impurity (R-Isomer)

  • CAT NUMBER DCTI-C-1995
  • CAS NUMBER 1955522-07-2 (free acid)
  • MOLECULAR FORMULA C21H29N4O10P (Free base) C22H30N4O12P - (Salt)
  • MOLECULAR WEIGHT "528.45 (Free base) 573.47 (Salt) "

Cytidine Isopropyl Impurity (S-Isomer)

  • CAT NUMBER DCTI-C-1994
  • CAS NUMBER 1955522-08-3 (free acid)
  • MOLECULAR FORMULA C21H29N4O10P (Free base); C22H30N4O12P - (Salt)
  • MOLECULAR WEIGHT 528.45 (Free base) ; 573.47 (Salt)

L-Cytidine

  • CAT NUMBER DCTI-C-1996
  • CAS NUMBER 26524-60-7
  • MOLECULAR FORMULA C9H13N3O5
  • MOLECULAR WEIGHT 243.22

General Information

Cytidine Impurities and Cytidine

Daicel Pharma synthesizes Cytidine impurities of exceptional quality, such as Cytidine 2-Ethylbutyl Impurity (R-Isomer), Cytidine 2-Ethylbutyl Impurity (S-Isomer), Cytidine 2-Ethylbutyl Sesamol Impurity (R-Isomer), Cytidine 2-Ethylbutyl sesamol Impurity (S-Isomer), Cytidine Isopropyl Impurity, Cytidine Isopropyl Impurity (R-Isomer), Cytidine Isopropyl Impurity (S-Isomer) and L-Cytidine. These impurities are crucial to assess the purity, reliability, and safety of Cytidine, an active pharmaceutical ingredient. Besides, Daicel Pharma provides custom synthesis of Cytidine impurities to meet clients’ demands for delivery worldwide.

Cytidine [CAS: 65-46-3] is a pyrimidine nucleoside. It comprises attaching cytosine to ribofuranose through a beta-N(1)-glycosidic bond. It is an RNA component and plays a role in various physiological processes.

Cytidine: Use and Commercial Availability  

Cytidine treats neuropsychiatric impairments associated with cerebrovascular diseases, often in combination with uridine, to enhance therapeutic effects. It serves as a pyrimidine compound that can be incorporated into nucleic acids and also acts as a substrate for the salvage pathway of pyrimidine nucleotide synthesis. The enzyme CTP synthase 1 (CTPS1) helps form Cytidine triphosphate, a vital precursor for DNA, RNA, and phospholipids.

Cytidine Structure and Mechanism of Action Cytidine Structure and Mechanism of Action

The chemical name of Cytidine is 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(amino)pyrimidin-2(1H)-one. Its chemical formula is C9H13N3O5, and its molecular weight is approximately 243.22 g/mol.

The mechanism of action of Cytidine is unknown.

Cytidine Impurities and Synthesis

Impurities in Cytidine can arise from various sources, including manufacturing1, raw materials, or degradation during storage. They can impact the purity and quality of Cytidine, potentially affecting its performance and safety. So, it is necessary to analyze and control these impurities. The common Cytidine impurities may include related substances, degradation products, and residual solvents. Analytical methods such as HPLC or LC help detect and quantify these impurities, ensuring that Cytidine meets the required quality standards for its intended use in research or pharmaceutical applications.

Daicel Pharma offers a Certificate of Analysis (CoA) for Cytidine impurity standards, such as Cytidine 2-Ethylbutyl Impurity (R-Isomer), Cytidine 2-Ethylbutyl Impurity (S-Isomer), Cytidine 2-Ethylbutyl Sesamol Impurity (R-Isomer), Cytidine 2-Ethylbutyl sesamol Impurity (S-Isomer), Cytidine Isopropyl Impurity, Cytidine Isopropyl Impurity (R-Isomer), Cytidine Isopropyl Impurity (S-Isomer) and L-Cytidine, generated from an analytical facility compliant with cGMP standards. The CoA includes a comprehensive characterization report comprising data from techniques like 1H NMR, 13C NMR, IR, MASS, and HPLC purity. Furthermore, on request, we give additional data like 13C-DEPT and CHN. Daicel Pharma can synthesize unknown Cytidine impurities or degradation products. A complete characterization report accompanies every delivery.

References
FAQ's

Frequently Asked Questions

Cytidine impurities are identified through comparison with reference standards, matching the retention time in chromatographic techniques, spectral analysis (such as UV, IR, or NMR), and other suitable analytical methods.

Yes, certain impurities in Cytidine can potentially impact its bioavailability. They may interfere with drug absorption, metabolism, or distribution, causing variations in drug concentration and efficacy.

Methanol is a solvent used for analyzing many impurities in Cytidine.

Cytidine impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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