General Information

Clobetasol Impurities and Clobetasol 

Daicel Pharma synthesizes high-quality Clobetasol impurities, Clobetasol 1,4,16-triene Impurity, Clobetasol Dipropionate 9-Fluoro Impurity, Clobetasol EP Impurity A, Clobetasol EP Impurity C, Clobetasol EP Impurity I, and Clobetasol propionate EP Impurity J, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient, Clobetasol. Moreover, Daicel Pharma offers custom synthesis of Clobetasol impurities and delivers them globally.

Topical corticosteroids, like Clobetasol [CAS: 25122-41-2], are synthetic steroids that treat inflammatory skin conditions and alleviate itching. These medicines have significantly improved the treatment of various inflammatory disorders.

Clobetasol: Use and Commercial Availability  

Clobetasol is a potent topical corticosteroid used for the short-term treatment of severe and stubborn inflammatory skin conditions that do not respond to less potent corticosteroids. These conditions include eczemas, dermatitis, psoriasis, lichen planus, alopecia areata, and chronic discoid lupus erythematosus. It is available as a topical medication under different brand names like Clobetasol Propionate, Clobex, Cormax, Embeline, Impeklo, Impoyz, Olux, etc.

Clobetasol Structure and Mechanism of Action

The chemical name of Clobetasol is (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione. Its chemical formula is C₂₂H₂₈ClFO_4, and its molecular weight is approximately 410.9 g/mol.

Clobetasol, like other corticosteroids, has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of action of Clobetasol is unknown.

Clobetasol Impurities and Synthesis

Clobetasol impurities¹ arise due to factors like process-related impurities, degradation products, and storage and handling. Degradation impurities occur due to oxidation, isomerization, hydrolysis, and reduction reactions. The presence of these impurities can affect the stability and safety of Clobetasol preparations and the need to control them.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Clobetasol impurity standards, Clobetasol 1,4,16-triene Impurity, Clobetasol Dipropionate 9-Fluoro Impurity, Clobetasol EP Impurity A, Clobetasol EP Impurity C, Clobetasol EP Impurity I, and Clobetasol propionate EP Impurity J. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We also provide a characterization report on delivery. Daicel has the technology and expertise to prepare any unknown Clobetasol impurity or degradation product.