General Information

Cefuroxime Impurities and Cefuroxime 

Daicel Pharma synthesizes high-quality Cefuroxime impurities, Cefuroxime axetil Delta-3 Isomers, and Cefuroxime axetil dimer, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Cefuroxime. Moreover, Daicel Pharma offers custom synthesis of Cefuroxime impurities and delivers them globally.

Cefuroxime [CAS: 55268-75-2] is an antibacterial medicine belonging to the group of second-generation cephalosporins. It is semi-synthetic and has a broad spectrum of activity against bacteria.

Cefuroxime: Use and Commercial Availability  

Cefuroxime is an antibiotic that treats various bacterial infections, including ear infections, bronchitis, skin infections, sinusitis, tonsillitis, gonorrhea, and urinary tract infections. It is available under brand names such as Zinacef, Ceftin, Cefuroxime Axetil, and Cefuroxime Sodium.

Cefuroxime Structure and Mechanism of Action

The chemical name of Cefuroxime is (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Its chemical formula is C₁₆H₁₆N₄O₈S, and its molecular weight is approximately 424.4 g/mol.

Cefuroxime inhibits bacterial cell wall synthesis and leads to cell lysis.

Cefuroxime Impurities and Synthesis

Cefuroxime is a cephalosporin antibiotic that is prone to the formation of impurities during its manufacturing¹ and storage. Impurities may form due to the degradation of the active pharmaceutical ingredient² or through the reaction of the active ingredient with other compounds. Controlling and minimizing the formation of impurities in Cefuroxime is critical to ensure its quality and safety for use in patients.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Cefuroxime impurity standards, Cefuroxime axetil Delta-3 Isomers, and Cefuroxime axetil dimer. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity³. We also provide 13C-DEPT and CHN on request. We give a complete characterization report on delivery. Daicel has the technology and expertise to prepare any unknown Cefuroxime impurity or degradation product.