Ceftazidime

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Ceftazidime-DCTI-C-1465-Daicel
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Ceftazidime EP impurity G

  • CAT Number DCTI-C-1465
  • CAS Number 194241-83-3
  • Molecular Formula C11H14N4O5S (free base) : C11H15ClN4O5S (with salt)
  • Molecular Weight 314.32 (free base) 350.77 (with salt)
Ceftazidime-DCTI-C-1464-Daicel
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Desacetylceftazidime Lactone Impurity

  • CAT Number DCTI-C-1464
  • CAS Number 1301254-50-1
  • Molecular Formula C17H17N5O7S2
  • Molecular Weight 467.47

General Information

Ceftazidime Impurities and Ceftazidime 

Daicel Pharma synthesizes high-quality Ceftazidime impurities, Ceftazidime EP impurity G, and Desacetylceftazidime Lactone Impurity, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Ceftazidime. Moreover, Daicel Pharma offers custom synthesis of Ceftazidime impurities and delivers them globally.

Ceftazidime [CAS: 72558-82-8] is a third-generation, semi-synthetic, broad-spectrum cephalosporin antibiotic for treating many bacterial infections.

Ceftazidime: Use and Commercial Availability  

Ceftazidime is an antibiotic used to treat many bacterial infections caused by susceptible organisms, including respiratory, skin, urinary tract, bone and joint, gynecologic, intra-abdominal, and central nervous system infections. Its combination with other medicines treats complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired and ventilator-associated bacterial pneumonia. The antibiotic is available as an injection under various brand names such as Ceptaz, Fortaz, Pentacef, Tazidime, and Tazicef.

Ceftazidime Structure and Mechanism of Action Ceftazidime Structure and Mechanism of Action

The chemical structure of Ceftazidime is 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]- Pyridinium. Its chemical formula is C22H22N6O7S2, and its molecular weight is approximately 546.6 g/mol.

Ceftazidime inhibits enzymes responsible for bacterial cell wall synthesis. It is active against gram-positive organisms. Further, it is active against the strains of organisms resistant to ampicillin and other cephalosporins.

Ceftazidime Impurities and Synthesis

Ceftazidime synthesis1 may result in the formation of impurities. Some impurities of Ceftazidime are related to the starting materials, reagents, or intermediates used during preparation. These impurities may include diastereoisomers, degradation products, and related substances. Manufacturers should ensure to control and minimize impurity formation so that Ceftazidime meets regulatory requirements for safety and efficacy.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Ceftazidime impurity standards, Ceftazidime EP impurity G, and Desacetylceftazidime Lactone Impurity. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2,3. We also provide 13C-DEPT and CHN on request. We give a complete characterization report on delivery. Daicel has the technology and expertise to prepare any unknown Ceftazidime impurity or degradation product.

References
FAQ's

Frequently Asked Questions

Various analytical techniques, including high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), etc., identify the impurities of Ceftazidime.

Impurities in Ceftazidime are minimized during storage and transportation by controlling temperature, humidity, and light exposure and using appropriate packaging materials.

Methanol is the solvent for analyzing most of the Ceftazidime impurities.

Ceftazidime impurities should be stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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