General Information

Cefepime Impurities and Cefepime 

Daicel Pharma synthesizes high-quality Cefepime impurity, Cefepime sulfoxides, which is crucial in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient Cefepime. Moreover, Daicel Pharma offers custom synthesis of Cefepime impurities and delivers them globally.

Cefepime [CAS: 88040-23-7] is a fourth-generation cephalosporin that treats bacterial infections caused by gram-negative and gram-positive bacteria. It belongs to the beta-lactam class of antibiotics.

Cefepime: Use and Commercial Availability 

Cefepime is a medicine recommended for treating pneumonia caused by susceptible bacteria. It acts as an initial therapy for patients with febrile neutropenia. Cefepime treats uncomplicated and complicated urinary tract infections (including pyelonephritis), uncomplicated skin and skin structure infections, and complicated intra-abdominal infections (when used with metronidazole).

Cefepime is available under the brand name such as Maxipime.

Cefepime Structure and Mechanism of Action

The chemical name of Cefepime is 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl- Pyrrolidinium. Its chemical formula is C₁₉H₂₄N₆O₅S₂, and its molecular weight is approximately 480.6 g/mol.

Cefepime is a bactericidal agent that inhibits bacterial cell wall synthesis. It is effective against Gram-positive and Gram-negative bacteria.

Cefepime Impurities and Synthesis

Cefepime impurities can be related substances, degradation products, or residual solvents formed during the drug’s manufacturing process¹. It is crucial to monitor and control these impurities to ensure patient safety.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for the Cefepime impurity standard, Cefepime sulfoxides. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We also provide 13C-DEPT and CHN on request. We give a complete characterization report on delivery. Daicel has the technology and expertise to prepare any unknown Cefepime impurity or degradation product.