General Information

Bupropion Impurities and Bupropion  

Daicel Pharma synthesizes Bupropion impurities of exceptional quality, such as (3S,5R,6R)- Bupropion Impurity, (3S,5S,6S)- Bupropion Impurity, 1-(3-chlorophenyl)-2-hydroxypropan-1-one, and so on. These impurities are crucial to assess the purity, reliability, and safety of Bupropion, an active pharmaceutical ingredient. Besides, Daicel Pharma provides custom synthesis of Bupropion impurities to meet clients’ demands for worldwide delivery.

Bupropion [CAS: 34911-55-2] is an aminoketone antidepressant that treats depression and helps patients quit smoking. It belongs to a novel class of antidepressants that differs structurally from most first-generation tricyclics and second-generation SSRI antidepressants. It treats excessive daytime sleepiness (EDS) associated with narcolepsy.

Bupropion: Use and Commercial Availability  

Bupropion, an antidepressant drug, also helps in smoking cessation. It treats the major depressive disorder. Further, it treats EDS associated with narcolepsy. Some of the brand names under which Bupropion is available as Aplenzin, Forfivo Xl, Wellbutrin, and Zyban.

Bupropion Structure and Mechanism of Action

The chemical name of Bupropion is 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one. Its chemical formula is C₁₃H₁₈ClNO, and its molecular weight is approximately 239.74 g/mol.

The mechanism of action of Bupropion is unknown.

Bupropion Impurities and Synthesis

Impurities in Bupropion form during its synthesis¹, storage, and transportation affect the drug’s purity, stability, efficacy, and safety. Common impurities include related compounds, residual solvents, and degradation products. These impurities can cause toxic and carcinogenic effects. So, it is necessary to control them in Bupropion through strict quality control measures and analytical methods during their manufacturing, storage, and distribution to ensure their safety and efficacy for patients.

Daicel Pharma offers a Certificate of Analysis (CoA) for Bupropion impurity standards, such as (3S,5R,6R)- Bupropion Impurity, (3S,5S,6S)- Bupropion Impurity, 1-(3-chlorophenyl)-2-hydroxypropan-1-one, and so on, generated from an analytical facility compliant with cGMP standards. The CoA includes a comprehensive characterization report comprising data from techniques like 1H NMR, 13C NMR, IR, MASS, and HPLC purity^2,3. Furthermore, on request, we can provide additional data like 13C-DEPT and CHN. Daicel Pharma can synthesize unknown Bupropion impurities or degradation products and labeled compounds to assess the effectiveness of generic Bupropion. We also offer Bupropion Hydrochloride-D9, Erythro-Dihydro Bupropion.HCl – D9, Hydroxy Bupropion-D6, and Threo-Dihydro Bupropion.HCl – D9, deuterium-labeled Bupropion compounds useful in bio-analytical research, such as BA/BE studies. A complete characterization report accompanies every delivery.