General Information

Aztreonam Impurities and Aztreonam 

Daicel Pharma synthesizes high-quality Aztreonam impurities, including Aztreonam Ethyl ester and Aztreonam tert-butyl ester. These impurities are essential for evaluating the quality, stability, and safety of Aztreonam, which is an active pharmaceutical ingredient. Additionally, Daicel Pharma offers a customized synthesis of Aztreonam impurities for global delivery to meet the specific needs of our customers.

Aztreonam [CAS: 78110-38-0] is an antibiotic of the monobactam class. It is effective against aerobic gram-negative bacilli that are resistant to many beta-lactamases. It was initially extracted from Chromobacterium violaceum with bactericidal activity. Aztreonam treats infections caused by gram-negative aerobic microorganisms.

Aztreonam: Use and Commercial Availability  

Aztreonam is a β-lactam antibiotic that treats or prevents infections caused by susceptible bacteria. It is effective against gram-negative aerobic bacteria. It improves respiratory symptoms in cystic fibrosis (CF) patients with Pseudomonas aeruginosa. The drug is available under the brand names Azactam and Cayston.

Aztreonam Structure and Mechanism of Action

The chemical name of Aztreonam is 2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid. Its chemical formula is C₁₃H₁₇N₅O₈S₂, and its molecular weight is approximately 435.4 g/mol.

Aztreonam binds to penicillin-binding bacteria, thus inhibiting bacterial cell wall synthesis and cell death.

Aztreonam Impurities and Synthesis

Aztreonam is a beta-lactam antibiotic that can cause the formation of impurities during its manufacturing process¹. These impurities can arise from various sources, including starting materials, synthetic intermediates, and degradation products. Some of these impurities can be potentially toxic and may risk patient safety. Therefore, it is crucial to monitor and control the levels of Aztreonam impurities to ensure the safety and efficacy of the drug.

Daicel Pharma provides a Certificate of Analysis (CoA) for Aztreonam impurity standards, including Aztreonam Ethyl ester and Aztreonam tert-butyl ester. The CoA is generated from a cGMP-compliant analytical facility and includes comprehensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We can also give additional characterization data like 13C-DEPT and CHN upon request. Daicel Pharma is capable of creating unknown Aztreonam impurities or degradation products. Each delivery has a complete characterization report.