Azilsartan

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2′-Carboxy Azilsartan Methyl Ester

  • CAT NUMBER DCTI-C-3223
  • CAS NUMBER 1675221-59-6
  • MOLECULAR FORMULA C25H22N2O5
  • MOLECULAR WEIGHT 430.46

Azilsartan AZLRC-10

  • CAT Number DCTI-C-1821
  • CAS Number NA
  • Molecular Formula C53H38N8O12
  • Molecular Weight 978.93
Azilsartan Hydroxy Acid
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Azilsartan Hydroxy Acid

  • CAT Number DCTI-C-1335
  • CAS Number 1397836-49-5
  • Molecular Formula C24H22N4O4
  • Molecular Weight 430.46
Azilsartan Impurity 23 (A-8443)
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Azilsartan Impurity 23 (A-8443)

  • CAT Number DCTI-C-1334
  • CAS Number 1821386-21-3
  • Molecular Formula C22H18N4O4
  • Molecular Weight 402.41

Azilsartan medoxomil-Amide Impurity

  • CAT NUMBER DCTI-C-2646
  • CAS NUMBER 1696392-12-7
  • MOLECULAR FORMULA C29H25N3O7
  • MOLECULAR WEIGHT 527.53

Azilsartan Medoxomil-Desethoxy Impurity

  • CAT NUMBER DCTI-C-2645
  • CAS NUMBER NA
  • MOLECULAR FORMULA C28H20N4O8
  • MOLECULAR WEIGHT 540.49

Azilsartan medoxomil-Dimer Impurity

  • CAT NUMBER DCTI-C-2647
  • CAS NUMBER 1604812-35-2
  • MOLECULAR FORMULA C35H28N4O11
  • MOLECULAR WEIGHT 680.63

Desethylazilsartan Nitrile Methyl Ester

  • CAT NUMBER DCTI-C-3198
  • CAS NUMBER 139481-33-7
  • MOLECULAR FORMULA C23H17N3O3
  • MOLECULAR WEIGHT 383.41

Desethylazilsartan Nitrile Methyl Ester

  • CAT NUMBER DCTI-C-3198
  • CAS NUMBER 139481-33-7
  • MOLECULAR FORMULA C23H17N3O3
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General Information

Azilsartan Impurities and Azilsartan 

Daicel Pharma provides high-quality Azilsartan impurities, including Azilsartan AZLRC-10, Azilsartan Hydroxy Acid, Azilsartan Impurity 23 (A-8443), Azilsartan medoxomil-Amide Impurity, Azilsartan Medoxomil-Desethoxy Impurity, Azilsartan medoxomil-Dimer Impurity, and Ethyl-2-ethoxy-3-((2′-(N’-hydroxycarbamimidoyl). These impurities are essential for evaluating the quality, stability, and safety of Azilsartan, which is an active pharmaceutical ingredient. Additionally, Daicel Pharma offers a customized synthesis of Azilsartan impurities for global delivery to meet the specific needs of our customers.

Azilsartan [CAS: 147403-03-0] is a medication that manages and treats hypertension. Its primary functions are to block the angiotensin receptors and act as an antihypertensive agent. It is a benzimidazole carboxylic acid derivative.

Azilsartan: Use and Commercial Availability  

Azilsartan is a drug that belongs to angiotensin II receptor blockers (ARBs) and is commercially available as Azilsartan medoxomil or in combination with other hypertensives. Azilsartan medoxomil is a prodrug, which hydrolyses to Azilsartan in the gastrointestinal tract during

absorption. Further, it prevents the recurrence of atrial fibrillation. It is available under the brand name Edarbi.

Azilsartan Structure and Mechanism of Action Azilsartan Structure and Mechanism of Action

The chemical name of Azilsartan is 1-[[2′-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid. Its chemical formula is C25H20N4O5, and its molecular weight is approximately 456.4 g/mol.

Azilsartan selectively blocks the binding of angiotensin II to the AT1 receptor in tissues like vascular smooth muscle and the adrenal gland, thus blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II.

Azilsartan Impurities and Synthesis

During manufacturing1, Azilsartan impurities arise due to various factors such as starting materials, synthetic processes, and degradation products. These impurities can affect the drug’s quality, safety, and efficacy, making it necessary to control them.

Daicel Pharma provides a Certificate of Analysis (CoA) for Azilsartan impurity standards, including Azilsartan AZLRC-10, Azilsartan Hydroxy Acid, Azilsartan Impurity 23 (A-8443), Azilsartan medoxomil-Amide Impurity, Azilsartan Medoxomil-Desethoxy Impurity, Azilsartan medoxomil-Dimer Impurity, and Ethyl-2-ethoxy-3-((2′-(N’-hydroxycarbamimidoyl). The CoA is generated from a cGMP-compliant analytical facility and includes comprehensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We can also give additional characterization data like 13C-DEPT and CHN on request. Daicel Pharma is capable of creating unknown Azilsartan impurities or degradation products. Each delivery has a complete characterization report.

References
FAQ's

Frequently Asked Questions

Genotoxic impurities are substances that can damage DNA and potentially cause cancer. They are typically present in low levels of drug substances.

Impurities in Azilsartan can be minimized during manufacturing by using high-quality starting materials, optimizing reaction conditions, and implementing appropriate purification steps.

Impurities in Azilsartan can vary between batches due to factors such as the quality of starting materials, manufacturing process, and storage conditions.

Azilsartan impurities are stored at recommended temperature conditions, typically 2-8°C or -20°C depending on their stability.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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