Adrenaline

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Adrenaline Impurity – F

  • CAT Number DCTI-C-024
  • CAS Number 78995-75-2
  • Molecular Formula C9H13NO5S
  • Molecular Weight 247.27

Adrenaline Impurity 12 Acetate Salt

  • CAT NUMBER DCTI-C-3290
  • CAS NUMBER 150-10-7(Free Base)
  • MOLECULAR FORMULA Free Base: C10H13NO3; Acetate Salt: C12H16NO5
  • MOLECULAR WEIGHT Free Base:195.22; Acetate Salt:254.26

General Information

Adrenaline Impurities and Adrenaline 

Daicel Pharma synthesizes high-quality Adrenaline impurity, Adrenaline Impurity – F, which is crucial in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient Adrenaline. Moreover, Daicel Pharma offers custom synthesis of Adrenaline impurities and delivers them globally.

Adrenaline [CAS: 51-43-4], or therapeutic Epinephrine, is a synthetic derivative of the endogenous sympathomimetic amine. It has vasoconstrictive, bronchodilatory, and intraocular pressure-lowering activities. Epinephrine (Adrenaline) is a hormone and neurotransmitter produced by adrenal glands. It is for emergency treatment of severe allergic reactions.

Adrenaline: Use and Commercial Availability  

Adrenaline is a widely used medicine that treats severe allergic reactions (anaphylaxis), maintains pupil dilation during eye surgeries, and treats septic shock-induced hypotension. Adrenaline is used as a local anesthetic. It acts on the body’s stress response by stimulating the sympathetic nervous system. There are many brand names for Adrenaline, including Adrenaclick, Auvi-Q, Duranest, Epipen, etc.

Adrenaline Structure and Mechanism of ActionAdrenaline Structure and Mechanism of Action

The chemical name of Adrenaline is 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol. Its chemical formula is C9H13NO3, and its molecular weight is approximately 183.20 g/mol.

Adrenaline is a sympathomimetic acting on alpha and beta receptors. Its vasoconstrictor action on alpha receptors increases vascular permeability leading to loss of intravascular fluid volume and hypotension during anaphylactic reactions. Further, its action on beta receptors causes bronchial smooth muscle relaxation that alleviates wheezing.

Adrenaline Impurities and Synthesis

Impurities form during manufacturing1, storage, or use of Adrenaline. These can be organic such as process-related or degradation products, or inorganic. It is necessary to control impurities to ensure the safety and efficacy of the medicine with regular testing and monitoring.

Daicel provides a Certificate of Analysis (CoA) for the Adrenaline impurity standard, Adrenaline Impurity – F. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data2,3, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Adrenaline impurity or degradation product. We give a complete characterization report on delivery.

References
FAQ's

Frequently Asked Questions

The impurities can affect the potency of Adrenaline, potentially reducing its effectiveness in treating some conditions.

Impurities can accelerate the degradation of Adrenaline, leading to shorter shelf life.

Water is the solvent used in analyzing many impurities in Adrenaline.

Adrenaline impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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