Acetyl salicylic acid

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2-acetoxybenzoic 2-hydroxybenzoic anhydride

  • CAT Number DCTI-C-1782
  • CAS NUMBER 2708578-72-5
  • MOLECULAR FORMULA C16H12O6
  • MOLECULAR WEIGHT 300.27

Acetyl Salicylic Acid EP Impurity-B

  • CAT Number DCTI-C-1876
  • CAS Number 636-46-4
  • Molecular Formula C8H6O5
  • Molecular Weight 182.13

Acetyl Salicylic Acid EP Impurity-C

  • CAT Number DCTI-C-1877
  • CAS Number 69-72-7
  • Molecular Formula C7H6O3
  • Molecular Weight 138.12

Acetyl Salicylic Acid EP Impurity-E

  • CAT Number DCTI-C-1878
  • CAS Number 552-94-3
  • Molecular Formula C14H10O5
  • Molecular Weight 258.23

Acetyl Salicylic Acid EP Impurity-F

  • CAT Number DCTI-C-1879
  • CAS Number 1466-82-6
  • Molecular Formula C18H14O7
  • Molecular Weight 342.3

Methyl 5-acetylsalicylate

  • CAT NUMBER DCTI-C-2089
  • CAS NUMBER 16475-90-4
  • MOLECULAR FORMULA C10H10O4
  • MOLECULAR WEIGHT 194.19

General Information

Acetyl Salicylic Acid Impurities and Acetyl Salicylic Acid 

Daicel Pharma synthesizes high-quality Acetyl Salicylic Acid impurities like Acetyl Salicylic Acid EP Impurity-B, Acetyl Salicylic Acid EP Impurity-C, Methyl 5-acetylsalicylate, 2-acetoxybenzoic 2-hydroxybenzoic anhydride, and more, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Acetyl Salicylic Acid. Moreover, Daicel Pharma offers custom synthesis of Acetyl Salicylic Acid impurities and delivers them globally.

Aspirin, also known as acetylsalicylic acid [CAS: 50-78-2], is a widely used analgesic and antipyretic medicine and has been used clinically for a long time. It is an orally administered non-steroidal anti-inflammatory agent with analgesic, antipyretic, and anticoagulant properties.

Acetyl Salicylic Acid: Use and Commercial Availability 

Acetylsalicylic acid acts as an analgesic, antipyretic, and anti-inflammatory medicine. Additionally, aspirin has anticoagulant properties and is used in low doses over a long period to prevent heart attacks and cancer. Aspirin treats many conditions, including angina pectoris, ankylosing spondylitis, fever, osteoarthritis, pain, rheumatoid arthritis, and systemic lupus erythematosus, and prevents myocardial infarction, ischemic stroke, and revascularization procedures. The drug is available under many trade names, including Aggrenox, Axotal, Codoxy, Fiorinal, etc.

Acetyl Salicylic Acid Structure and Mechanism of ActionAcetyl Salicylic Acid Structure and Mechanism of Action

The chemical formula for Acetyl Salicylic Acid (Aspirin) is C9H8O4, and its molecular weight is approximately 180.16 g/mol.

Aspirin inhibits the activity of the cyclooxygenase (COX) enzyme, which leads to prostaglandins formation and causes inflammation, pain, and fever.

Acetyl Salicylic Acid Impurities and Synthesis

Impurities in acetylsalicylic acid arise from various factors such as the quality of the starting materials, synthetic1 processes, and storage conditions. They produce from starting materials, byproducts, or degradation of the drug substance. The formation of these impurities affects the purity and efficacy of the drug product, and hence, it is necessary to monitor and control the levels of acetylsalicylic acid impurities.

Daicel provides a Certificate of Analysis (CoA) for Acetyl Salicylic Acid impurity standards, including Acetyl Salicylic Acid EP Impurity-B, Acetyl Salicylic Acid EP Impurity-C, Methyl 5-acetylsalicylate, 2-acetoxybenzoic 2-hydroxybenzoic anhydride, and more. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Acetyl Salicylic Acid impurity or degradation product. We give a complete characterization report on delivery.

References
FAQ's

Frequently Asked Questions

Impurities in Acetyl Salicylic Acid impurities (Aspirin) are detected using analytical techniques such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), etc.

Impurities in Acetyl Salicylic Acid impurities (Aspirin) are rare, but poor manufacturing practices, improper handling of raw materials, or inadequate quality control measures can generate them.

Methanol is the solvent used in analyzing many impurities in Acetyl Salicylic Acid.

Acetyl Salicylic Acid impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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