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Bupropion - NDSRI's
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N-Nitroso Bupropion

  • CAT NUMBER DCTI-C-3077
  • CAS NUMBER 2763780-10-3
  • MOLECULAR FORMULA C13H17ClN2O2
  • MOLECULAR WEIGHT 268.74
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References
FAQ's

References

  1. Mehta, Nariman B.; Yeowell, David A., Meta Chloro Substituted-Alpha-Butylamino-Propiophenones, Wellcome Foundation Ltd., US3819706A, June 25, 1974
  2. Cooper, Thomas B.; Suckow, Raymond F.; Glassman, Alexander, Determination of bupropion and its major basic metabolites in plasma by liquid chromatography with dual-wavelength ultraviolet detection, Journal of Pharmaceutical Sciences, Volume: 73, Issue: 8, Pages: 1104-7, 1984
  3. Al-Khamis, Khalil I., Rapid determination of bupropion in human plasma by high-performance liquid chromatography, Journal of Liquid Chromatography, Volume: 12, Issue: 4, Pages: 645-55, 1989

Frequently Asked Questions

Impurity testing should be conducted at regular intervals during drug development, including during the synthesis of the API, production of drug products, and stability studies. The testing frequency depends on the regulatory requirements and the risk associated with the impurities.

Yes, impurities in Bupropion can affect the drug efficacy by reducing the potency of the API or interfering with its mechanism of action.

The detection of impurities in Bupropion is through analytical methods such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), etc.

Bupropion impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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